KDM6A and HIST3H3

Number of citations of the paper that reports this interaction (PMID 17761849)
170

Data Source:
BioGRID (enzymatic study)

		KDM6A	HIST3H3
Gene Name		lysine (K)-specific demethylase 6A	histone cluster 3, H3
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Respiratory System Process Chromatin Organization Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Multicellular Organism Growth Mesodermal Cell Differentiation Notochord Morphogenesis Histone H3-K4 Methylation Oxidation-reduction Process Canonical Wnt Signaling Pathway Histone H3-K27 Demethylation	Telomere Maintenance
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones	DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: HIST1H3A HIST2H3C HIST3H3 NKX2-5 SMAD9 SRF TBX5 TLE1	183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516
Entrez ID		7403	8290
HPRD ID		02131	04156
Ensembl ID		ENSG00000147050	ENSG00000168148
Uniprot IDs		F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3	Q16695
PDB IDs		3AVR 3AVS	2V1D 2YBP 2YBS 3A6N 3T6R
Enriched GO Terms of Interacting Partners?		Bundle Of His Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cardiac Muscle Cell Differentiation DNA Methylation On Cytosine Cardiac Ventricle Formation Cardiac Chamber Formation Cardiac Conduction System Development Nitrogen Compound Metabolic Process Cardiocyte Differentiation Gene Expression Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing At RDNA Coronary Vasculature Development Cardiac Chamber Development Heart Trabecula Formation Positive Regulation Of DNA-templated Transcription, Initiation Atrial Septum Morphogenesis Atrial Septum Development Regulation Of DNA-templated Transcription, Initiation Cardiac Myofibril Assembly Cardiac Muscle Tissue Development Heart Trabecula Morphogenesis Regulation Of Transcription, DNA-templated Heart Morphogenesis Regulation Of Nucleic Acid-templated Transcription Striated Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process Cardiac Atrium Morphogenesis Tube Development Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Chromatin Silencing Regulation Of Developmental Growth Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cell Differentiation Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Trabecula Morphogenesis Striated Muscle Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Differentiation Sarcomere Organization Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression
Tagcloud ?		aacr bladder brca2 carriers clin clinicopathologic discovering drivers ercc2 exome fancd2 multimodality mutational noncarriers palb2 perioperative pt2 ptn res resected rfs somatic staging suboptimal tsc1 unc5c undiscovered usage warranted	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		aacr bladder brca2 carriers clin clinicopathologic discovering drivers ercc2 exome fancd2 multimodality mutational noncarriers palb2 perioperative pt2 ptn res resected rfs somatic staging suboptimal tsc1 unc5c undiscovered usage warranted	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?