TYK2 and PTPRC

Number of citations of the paper that reports this interaction (PMID 11201744)
76

Data Source:
HPRD (in vitro)

		TYK2	PTPRC
Gene Name		tyrosine kinase 2	protein tyrosine phosphatase, receptor type, C
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation
Pathways		Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Interferon alpha/beta signaling NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Interferon Signaling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation	TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Psoriasis ( 20953190) Type 1 diabetes ( 19966805) Type 1 diabetes autoantibodies ( 21829393)	Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		36 interactors: CBL COPS5 CRKL DNM2 EIF2AK2 FHL3 FYN GHR GNB2L1 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KRT40 LYN PDGFRB PIK3R1 PLAUR PRMT5 PTAFR PTPN1 PTPN6 PTPRC STAM2 STAT1 STAT2 TK1 TRAF4 VAV1 XRCC5	43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70
Entrez ID		7297	5788
HPRD ID		01490	01050
Ensembl ID		ENSG00000105397	ENSG00000081237
Uniprot IDs		P29597	M9MML4 P08575
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ	1YGR 1YGU
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Organic Substance Regulation Of Immune Response Response To Growth Hormone Regulation Of Immune System Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Defense Response Regulation Of Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Immune Response Cell Surface Receptor Signaling Pathway Immune System Process Signal Transduction Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Kinase Activity Signaling Cell Communication Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Response To Cytokine Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Lymphocyte Activation Viral Process Fibroblast Growth Factor Receptor Signaling Pathway Response To Stimulus	Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		3t3 carboxyl coimmunoprecipitated directed f442a functionally gh ghr heretofore hmw immunoblotting immunologically immunoprecipitation independently jak1 jak2 jak3 janus kd member mr physically preadipocytes referred signalling step terminus tyrosine whose	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Difference) ?		3t3 carboxyl coimmunoprecipitated directed f442a functionally gh ghr heretofore hmw immunoblotting immunologically immunoprecipitation independently jak1 jak2 jak3 janus kd member mr physically preadipocytes referred signalling step terminus tyrosine whose	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Intersection) ?