TSHB and TSHR

Number of citations of the paper that reports this interaction (PMID 2558651)
43

Data Source:
HPRD (in vivo)

		TSHB	TSHR
Gene Name		thyroid stimulating hormone, beta	thyroid stimulating hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Hormone Activity	Thyroid-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Anatomical Structure Morphogenesis Peptide Hormone Processing Response To Vitamin A Response To Estrogen Cellular Protein Metabolic Process Response To Calcium Ion	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell-cell Signaling Positive Regulation Of Cell Proliferation Thyroid-stimulating Hormone Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Amine-derived hormones G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Metabolism of amino acids and derivatives Peptide hormone metabolism GPCR downstream signaling Glycoprotein hormones Thyroxine biosynthesis Peptide hormone biosynthesis	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Thyrotropin Alfa
Diseases
GWAS			Graves' disease ( 21841780) Hair morphology ( 19896111) Optic disc size (rim) ( 20395239) Visceral fat ( 22589738)
Protein-Protein Interactions		2 interactors: CGA TSHR	24 interactors: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB UBC
Entrez ID		7252	7253
HPRD ID		11766	04537
Ensembl ID		ENSG00000134200	ENSG00000165409
Uniprot IDs		P01222	F5GYU5 P16473
PDB IDs			1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?		Thyroid-stimulating Hormone Signaling Pathway Regulation Of Locomotion Positive Regulation Of Cell Proliferation Dopaminergic Neuron Differentiation Cell-cell Signaling Inner Ear Receptor Stereocilium Organization Cochlea Morphogenesis Peptide Hormone Processing Inner Ear Receptor Cell Development Regulation Of Cell Proliferation Cochlea Development Positive Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Platelet Activation Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Signaling Cell Communication Response To Stress Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell Activation Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Response To Stimulus Regulation Of Adenylate Cyclase Activity Developmental Process Regulation Of Cyclase Activity Cellular Response To Stimulus Regulation Of CAMP Biosynthetic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Localization Anatomical Structure Development Establishment Of Localization In Cell Regulation Of Signaling Regulation Of Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Motility Growth Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Growth Hormone Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Differentiation Multicellular Organismal Development Activation Of Adenylate Cyclase Activity Response To Cytokine Regulation Of Cellular Process Cellular Response To Organic Substance
Tagcloud ?		cga deiodinase dio2 hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Difference) ?		cga deiodinase dio2 hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroidal thyroxine trh trhr triiodothyronine	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten toxic twenty
Tagcloud (Intersection) ?		thyroid thyrotropin