TP53BP1 and SPAG9

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TP53BP1	SPAG9
Gene Name		tumor protein p53 binding protein 1	sperm associated antigen 9
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm	Acrosomal Vesicle Cytoplasm Cytosol Integral Component Of Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Cofactor Activity P53 Binding Damaged DNA Binding Protein Binding Methylated Histone Binding Telomeric DNA Binding	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Activation Of JUN Kinase Activity Spermatogenesis Positive Regulation Of Cell Migration Retrograde Transport, Endosome To Golgi Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Protein Homooligomerization Negative Regulation Of Protein Homodimerization Activity
Pathways		Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ARAP1 ATM BLM BRCA1 CCNB1 CDK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AFX HIST1H4A HIST2H4A HIST4H4 IFI16 LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 PAXIP1 PCNT PLK1 RAD18 RELA SPAG9 TFDP1 TP53 USP28 VAC14	11 interactors: KLC1 MAP1LC3B MAP2K4 MAP3K3 MAPK14 MAPK8 MAX MYC NFKB1 PNRC2 TP53BP1
Entrez ID		7158	9043
HPRD ID		05569	10398
Ensembl ID		ENSG00000067369	ENSG00000008294
Uniprot IDs		F8VY86 Q12888	O60271 Q5JB53
PDB IDs		1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0	2W83
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Process DNA Damage Checkpoint DNA Metabolic Process Response To Abiotic Stimulus Response To Radiation Mitotic Cell Cycle Process Cell Cycle Checkpoint DNA Repair Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Response To Stress Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cell Death Telomere Maintenance Death Apoptotic Signaling Pathway DNA Recombination Intracellular Signal Transduction Regulation Of Metabolic Process G2 DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Phase Transition Histone Modification Cell Cycle Phase Transition Apoptotic Process DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Programmed Cell Death DNA Packaging Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade Toll-like Receptor 4 Signaling Pathway Signal Transduction By Phosphorylation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Response To Stress Response To Stress Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Innate Immune Response Cellular Response To Mechanical Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Immune Response-regulating Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Response To External Stimulus Response To Abiotic Stimulus Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Response To Growth Factor Response To Mechanical Stimulus Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Organelle Disassembly Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction
Tagcloud ?		abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt	afp antigen behavior bel biomarker colony contributes correlated cyclin depletion downregulated hcc hepatocellular immunohistochemistry interfering knockdown malignant marker mtt multiplicity overexpressed overexpression pattern poor relapse serves sirna sperm transfection
Tagcloud (Difference) ?		abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt	afp antigen behavior bel biomarker colony contributes correlated cyclin depletion downregulated hcc hepatocellular immunohistochemistry interfering knockdown malignant marker mtt multiplicity overexpressed overexpression pattern poor relapse serves sirna sperm transfection
Tagcloud (Intersection) ?