C1R and PCK1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		C1R	PCK1
Gene Name		complement component 1, r subcomponent	phosphoenolpyruvate carboxykinase 1 (soluble)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity	Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding GDP Binding Manganese Ion Binding Carboxylic Acid Binding
	Biological Process	Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Innate Immune Response	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Internal Protein Amino Acid Acetylation Pathogenesis Response To Activity Drug Metabolic Process Response To Insulin Glucose Homeostasis Small Molecule Metabolic Process Glycerol Biosynthetic Process From Pyruvate
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Transcriptional regulation of white adipocyte differentiation Glycogen storage diseases Metabolism of carbohydrates Abacavir transport and metabolism Abacavir metabolism
Drugs			Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine Phosphomethylphosphonic Acid-Guanylate Ester
Diseases
GWAS			Response to fenofibrate (adiponectin levels) ( 23149075) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		7 interactors: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1	4 interactors: APP C1R FBXO25 IKBKG
Entrez ID		715	5105
HPRD ID		01954	02028
Ensembl ID			ENSG00000124253
Uniprot IDs		P00736	B4DT64 P35558
PDB IDs		1APQ 1GPZ 1MD7 1MD8 2QY0	1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Innate Immune Response Immune Response Defense Response Positive Regulation Of Immune Response Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune System Process Regulation Of Immune System Process Histone H2B Acetylation Glycerol Biosynthetic Process From Pyruvate Internal Protein Amino Acid Acetylation Negative Regulation Of Complement Activation, Lectin Pathway Response To Stimulus Protein Acetylation N-terminal Peptidyl-lysine Acetylation Glycerol Biosynthetic Process Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Positive Regulation By Host Of Viral Transcription Rhythmic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of Complement Activation Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Oxaloacetate Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Synaptic Growth At Neuromuscular Junction Intracellular Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Immune Response Defense Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling
Tagcloud ?		a2 allogeneic autologous candidates cold ctl ctls demonstrating encoded epitopes gastric her2 hla ic50 immunodominance immunotherapy implicate lymphocyte lysed naturally neu processed recognized repetitive restricted sensitize sw626 tal transfected	3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite picture preferential pyruvate redundant repressive suppressing tcf tcf7l2 tcf7l2dn views wnt
Tagcloud (Difference) ?		a2 allogeneic autologous candidates cold ctl ctls demonstrating encoded epitopes gastric her2 hla ic50 immunodominance immunotherapy implicate lymphocyte lysed naturally neu processed recognized repetitive restricted sensitize sw626 tal transfected	3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite picture preferential pyruvate redundant repressive suppressing tcf tcf7l2 tcf7l2dn views wnt
Tagcloud (Intersection) ?