TGIF1 and IRF2BP1

Number of citations of the paper that reports this interaction (PMID 18511908)
7

Data Source:
HPRD (two hybrid, in vivo)

		TGIF1	IRF2BP1
Gene Name		TGFB-induced factor homeobox 1	interferon regulatory factor 2 binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Aggresome Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Co-SMAD Binding	Protein Binding Ligase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organismal Development Determination Of Left/right Symmetry Negative Regulation Of Cell Proliferation Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gastrulation Nodal Signaling Pathway Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Retina Development In Camera-type Eye	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 PML SIN3A SMAD2 SMAD3 WWP1	7 interactors: ATF2 IRF2 IRF9 JDP2 PCBD2 SMAD1 TGIF1
Entrez ID		7050	26145
HPRD ID		04023	17159
Ensembl ID		ENSG00000177426	ENSG00000170604
Uniprot IDs		Q15583	Q8IU81
PDB IDs		2LK2
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Viral Process Positive Regulation Of Gene Expression Developmental Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Cell Differentiation DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Wounding Regulation Of Cell Proliferation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Defense Response Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cellular Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Interferon-gamma Positive Regulation Of Metabolic Process Response To Interferon-gamma Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Innate Immune Response Response To Transforming Growth Factor Beta Primary MiRNA Processing MAPK Cascade Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Osteoblast Fate Commitment Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Transcription From RNA Polymerase II Promoter Tetrahydrobiopterin Biosynthetic Process
Tagcloud ?		accordance advance af9 associating blasts circuitries doi effectors exit extension forced hematopoiesis homeodomain interferes leu leukemic maintenance mechanistically meis1 mll november online orchestrates publication rearranged repressors tale tgif2 uncharacterized	abundance collection colorectal dataset dissected front give healing igf1 immunohistochemical individually insights invasion knockout largest lymph lymphatic mx1 node nonmetastatic overexpressed phenotypes proteome quantified representing resolution validation wilcoxon wound
Tagcloud (Difference) ?		accordance advance af9 associating blasts circuitries doi effectors exit extension forced hematopoiesis homeodomain interferes leu leukemic maintenance mechanistically meis1 mll november online orchestrates publication rearranged repressors tale tgif2 uncharacterized	abundance collection colorectal dataset dissected front give healing igf1 immunohistochemical individually insights invasion knockout largest lymph lymphatic mx1 node nonmetastatic overexpressed phenotypes proteome quantified representing resolution validation wilcoxon wound
Tagcloud (Intersection) ?