HNF1A and ALB

Number of citations of the paper that reports this interaction (PMID 2460858)
87

Data Source:
HPRD (in vitro)

		HNF1A	ALB
Gene Name		HNF1 homeobox A	albumin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Extracellular Region Basement Membrane Extracellular Space Nucleus Platelet Alpha Granule Lumen Protein Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity	DNA Binding Fatty Acid Binding Copper Ion Binding Protein Binding Drug Binding Zinc Ion Binding Toxic Substance Binding Antioxidant Activity Oxygen Binding Enzyme Binding Pyridoxal Phosphate Binding Chaperone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Insulin Secretion Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Retina Homeostasis Platelet Degranulation Transport Receptor-mediated Endocytosis Response To Nutrient Blood Coagulation Bile Acid Metabolic Process Cellular Response To Starvation Response To Organic Substance Bile Acid And Bile Salt Transport Hemolysis By Symbiont Of Host Erythrocytes Platelet Activation Lipoprotein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Sodium-independent Organic Anion Transport Small Molecule Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Mercury Ion Maintenance Of Mitochondrion Location Transmembrane Transport Response To Platinum Ion
Pathways		Regulation of beta-cell development Regulation of gene expression in beta cells	Lipoprotein metabolism Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Recycling of bile acids and salts Platelet degranulation Lipid digestion, mobilization, and transport Transport of organic anions SLC-mediated transmembrane transport HDL-mediated lipid transport Scavenging of heme from plasma Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Transport of vitamins, nucleosides, and related molecules
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 21300955 22939635) C-reactive protein and white blood cell count ( 22788528) Cholesterol, total ( 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary heart disease ( 19198612) Gamma gluatamyl transferase levels ( 22010049) Gamma glutamyl transpeptidase ( 21909109) LDL cholesterol ( 19060906 20686565) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) N-glycan levels ( 21203500) Type 2 diabetes ( 21573907 20581827) Urate levels ( 23263486)	Lipid metabolism phenotypes ( 22286219) Prostate cancer ( 23535732)
Protein-Protein Interactions		21 interactors: AES ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1	24 interactors: AGA AMBP APOE APP CRYAA CUBN F7 FCGRT HNF1A IMMT KLK3 LRP2 LUC7L2 NR5A2 ORM1 PFDN1 PON1 PRB3 RBP4 RYR2 SRGN ST13 TK1 YWHAG
Entrez ID		6927	213
HPRD ID		00800	00062
Ensembl ID		ENSG00000135100	ENSG00000163631
Uniprot IDs		F5H5U3 P20823	C9JKR2 P02768
PDB IDs		1IC8 2GYP	1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2VDB 2VUE 2VUF 2XSI 2XVQ 2XVU 2XVV 2XVW 2XW0 2XW1 2YDF 3A73 3B9L 3B9M 3CX9 3JQZ 3JRY 3LU6 3LU7 3LU8 3SQJ 3TDL 3UIV 4E99 4EMX 4G03 4G04 4HGK 4HGM 4IW1 4IW2 4K2C 4L8U 4L9K 4L9Q 4LA0 4LB2 4LB9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Hormone Negative Regulation Of Gene Expression Response To Steroid Hormone Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Organ Development Intracellular Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Cell Communication System Development	Alcohol Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Chemical Homeostasis Lipid Metabolic Process Homeostatic Process Response To External Stimulus Response To Stimulus Phototransduction, Visible Light Retinoid Metabolic Process Tetrapyrrole Metabolic Process Vitamin D Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Regulation Of Blood Coagulation Response To Lipid Positive Regulation Of Cholesterol Efflux Reverse Cholesterol Transport Detection Of Light Stimulus Positive Regulation Of Cholesterol Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis System Development Isoprenoid Metabolic Process Small Molecule Metabolic Process Regulation Of Cholesterol Efflux Response To Hormone Regulation Of Wound Healing Organ Development Response To Light Stimulus Vesicle-mediated Transport Receptor-mediated Endocytosis Endocytosis Regulation Of Cellular Localization Response To Organic Substance Response To Wounding Response To Abiotic Stimulus Cellular Metal Ion Homeostasis Positive Regulation Of Transport Bile Acid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Cholesterol Transport Blood Coagulation Tissue Homeostasis Hemostasis Response To Nutrient Levels Heme Metabolic Process Multicellular Organismal Development
Tagcloud ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	ambulatory anabolic anthropometric calls capd catabolism causal complicating declined deterioration dialysis haemodialysis instead malnutrition mmol nutrineal nutrition osmotic peritoneal phosphates phosphorus rule solution substituted termination transferrin uraemic urea wilcoxon
Tagcloud (Difference) ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	ambulatory anabolic anthropometric calls capd catabolism causal complicating declined deterioration dialysis haemodialysis instead malnutrition mmol nutrineal nutrition osmotic peritoneal phosphates phosphorus rule solution substituted termination transferrin uraemic urea wilcoxon
Tagcloud (Intersection) ?