TCEA1 and PAF1

Number of citations of the paper that reports this interaction (PMID 20178742)
58

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		TCEA1	PAF1
Gene Name		transcription elongation factor A (SII), 1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Cdc73/Paf1 Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	RNA Polymerase II Core Binding Chromatin Binding Protein Binding
	Biological Process	DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Erythrocyte Differentiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Pathways		Nucleotide Excision Repair Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APP CDC73 CDK7 CIR1 CTDP1 CTR9 EAF2 GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 UBR5 WDR61	12 interactors: FXR2 HIST1H1C HIST1H3A KAT8 KMT2A LEO1 MLLT1 MSL1 MSL2 MSL3 RNF20 TCEA1
Entrez ID		6917	54623
HPRD ID		03252	10140
Ensembl ID		ENSG00000187735	ENSG00000006712
Uniprot IDs		B7Z4S1 P23193	M0QX35 Q8N7H5
PDB IDs		1TFI 3NDQ	4M6T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated MRNA Processing Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Histone H2B Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Gene Expression MRNA Metabolic Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Endodermal Cell Differentiation RNA Processing Regulation Of Nitrogen Compound Metabolic Process Endoderm Formation Transcription Elongation From RNA Polymerase II Promoter Stem Cell Maintenance Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Myeloid Cell Differentiation Endoderm Development MRNA Polyadenylation Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Histone Ubiquitination RNA Polyadenylation Negative Regulation Of Cell Differentiation Stem Cell Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Protein Monoubiquitination Regulation Of Histone Modification Wnt Signaling Pathway Formation Of Primary Germ Layer Positive Regulation Of Viral Transcription	Histone H4-K16 Acetylation Chromatin Organization Histone H4 Acetylation Chromosome Organization Histone Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Chromatin Modification Peptidyl-lysine Modification Organelle Organization Histone H2B Ubiquitination Histone Monoubiquitination Peptidyl-amino Acid Modification Regulation Of Gene Expression Histone Ubiquitination Positive Regulation Of Histone Methylation Protein Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Regulation Of DNA-templated Transcription, Elongation Cellular Protein Modification Process Regulation Of RNA Metabolic Process DNA Methylation Transcription, DNA-templated Positive Regulation Of Cellular Response To Drug Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression RNA Biosynthetic Process Positive Regulation Of Histone Modification Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process DNA Modification Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Protein Metabolic Process Nucleosome Assembly Regulation Of Histone Modification Chromatin Assembly Nucleosome Organization Regulation Of Metabolic Process Regulation Of Response To Drug
Tagcloud ?		arachnoid beforehand cdc25a cdk6 cluego cytoscape distinctive dysregulation helpful hub ifit ifit1 introduced mcm2 mcm7 mcode meningioma meningiomas meningothelial mined names neutralization ppi rbc sec31a seed subnetworks ube2e1 xrcc5	ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b destabilization dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats leo1 lytic parasite parasites phylum possessing proteomics protozoan redundant rrm tfiid toxoplasma
Tagcloud (Difference) ?		arachnoid beforehand cdc25a cdk6 cluego cytoscape distinctive dysregulation helpful hub ifit ifit1 introduced mcm2 mcm7 mcode meningioma meningiomas meningothelial mined names neutralization ppi rbc sec31a seed subnetworks ube2e1 xrcc5	ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b destabilization dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats leo1 lytic parasite parasites phylum possessing proteomics protozoan redundant rrm tfiid toxoplasma
Tagcloud (Intersection) ?