STXBP1 and NEFM

Number of citations of the paper that reports this interaction (PMID 12963086)
9

Data Source:
HPRD (in vivo)

		STXBP1	NEFM
Gene Name		syntaxin binding protein 1	neurofilament, medium polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Platelet Alpha Granule Protein Complex Extracellular Vesicular Exosome	Neurofilament Axon Neuromuscular Junction Neurofibrillary Tangle
	Molecular Function	SNARE Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding
	Biological Process	Platelet Degranulation Energy Reserve Metabolic Process Vesicle Docking Involved In Exocytosis Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Maturation Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion Protein Stabilization Long Term Synaptic Depression Platelet Aggregation Protein Localization To Plasma Membrane	Microtubule Cytoskeleton Organization Axon Cargo Transport Regulation Of Axon Diameter Neurofilament Bundle Assembly
Pathways		Integration of energy metabolism Regulation of insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APBA1 APBA2 APP CDK5 CDK5R1 DOC2A DOC2B DYT10 HGS MAPT NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SQSTM1 STX11 STX19 STX1A STX1B STX2 STX3 SYTL4 TRIM38 USO1	9 interactors: APOE DISC1 FOS MINK1 NEFH RB1 SMAD2 STXBP1 TNIK
Entrez ID		6812	4741
HPRD ID		04235	01205
Ensembl ID		ENSG00000136854	ENSG00000104722
Uniprot IDs		B7Z1V5 P61764 Q68CM6	E7EMV2 E7ESP9 P07197 Q9UK51
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Secretion Synaptic Vesicle Transport Cell-cell Signaling Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Secretion By Cell Neurotransmitter Transport Vesicle Fusion Establishment Of Vesicle Localization Vesicle Localization Secretion Establishment Of Organelle Localization Cellular Localization Exocytosis Organelle Fusion Vesicle Docking Intracellular Transport Membrane Docking Organelle Localization Membrane Fusion Protein Localization Regulation Of Exocytosis Regulation Of Cellular Localization Protein Transport Membrane Organization Establishment Of Protein Localization Intracellular Protein Transport Signaling Transport Cell Communication Vesicle Organization Positive Regulation Of Exocytosis Vesicle-mediated Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Peptidyl-threonine Phosphorylation Regulation Of Secretion Axon Cargo Transport Regulation Of Signaling Organelle Organization Positive Regulation Of Secretion Histone H3-T6 Phosphorylation Neurofilament Bundle Assembly Positive Regulation Of Transport Serine Phosphorylation Of STAT3 Protein Nervous System Development Regulation Of Synaptic Vesicle Transport	Cell Differentiation Nervous System Development System Development Generation Of Neurons Neurogenesis Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Cytoskeleton Organization Cell Projection Organization Developmental Process Positive Regulation Of Cellular Metabolic Process Neuron Projection Development Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Neuron Development Cell Development Regulation Of Signaling Protein Localization Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Cellular Protein Catabolic Process Neuron Differentiation Response To Cholesterol Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Protein Catabolic Process Cellular Protein Localization Cellular Localization MAPK Cascade Anatomical Structure Morphogenesis Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Signal Transduction By Phosphorylation Positive Regulation Of Proteolysis Regulation Of Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation SMAD Protein Signal Transduction Regulation Of Cell Development Skeletal Muscle Cell Differentiation Cell-cell Signaling Actin Cytoskeleton Reorganization Protein Localization To Membrane Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Intersection) ?