STAC and TRIP6

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		STAC	TRIP6
Gene Name		SH3 and cysteine rich domain	thyroid hormone receptor interactor 6
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	Protein Binding Metal Ion Binding	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Signal Transduction Cellular Response To Heat Intracellular Signal Transduction	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS		Erectile dysfunction ( 22704111)	Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		11 interactors: APP C9orf156 FBXO25 KANK2 KIAA1958 LIMD1 LMNA LZTS2 NCKIPSD NEDD4L TRIP6	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		6769	7205
HPRD ID		11890	04242
Ensembl ID		ENSG00000144681	ENSG00000087077
Uniprot IDs		E9PEA7 Q99469	F2ZC06 Q15654
PDB IDs		2DL4	1X61 2DLO
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Protein Localization To Nucleus Nucleocytoplasmic Transport Nuclear Transport Regulation Of Protein Localization Sterol Regulatory Element Binding Protein Import Into Nucleus Regulation Of Cellular Localization Response To Abiotic Stimulus Cytoskeleton Organization Negative Regulation Of Vitamin D Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Caveolin-mediated Endocytosis Protein Import Into Nucleus Nuclear Import Collateral Sprouting In Absence Of Injury Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Signal Transduction Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Canonical Wnt Signaling Pathway Protein Import Release Of Cytoplasmic Sequestered NF-kappaB Collateral Sprouting Axon Midline Choice Point Recognition Protein Localization To Nucleus Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Hippo Signaling Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Signaling Regulation Of Cellular Component Movement Cytoplasmic Transport Intracellular Transport Cell Communication Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Wnt Signaling Pathway Microtubule-based Process Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Regulation Of Hippo Signaling Positive Regulation Of Cell Aging Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nucleic Acid-templated Transcription	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		17p 1p36 1q 1q13 1q21 4q21 7p 7q 8p 8q 8q11 9p aspscr1 cirrhotic etv1and ffpe fgfr3 gains hcc hccs maf nearby pathologically pter q23 q26 recql4 xp xq	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		17p 1p36 1q 1q13 1q21 4q21 7p 7q 8p 8q 8q11 9p aspscr1 cirrhotic etv1and ffpe fgfr3 gains hcc hccs maf nearby pathologically pter q23 q26 recql4 xp xq	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?