SSTR3 and SST

Number of citations of the paper that reports this interaction (PMID 1337145)
16

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		SSTR3	SST
Gene Name		somatostatin receptor 3	somatostatin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Nonmotile Primary Cilium Neuron Projection Ciliary Membrane	Extracellular Region Extracellular Space Neuronal Cell Body
	Molecular Function	Somatostatin Receptor Activity Protein Binding Neuropeptide Binding	Hormone Activity
	Biological Process	Organelle Organization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Spermatogenesis Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Cerebellum Development Forebrain Development Somatostatin Signaling Pathway Response To Starvation Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes BBSome-mediated cargo-targeting to cilium GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors G alpha (i) signalling events	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Cysteamine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CORT GNAI1 LNX1 SST TP53	6 interactors: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6753	6750
HPRD ID		01675	08920
Ensembl ID		ENSG00000183473	ENSG00000157005
Uniprot IDs		P32745 Q86YF2	P61278
PDB IDs			1P2W
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Osmotic Stress Synaptic Transmission Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cell-cell Signaling Negative Regulation Of Helicase Activity G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Hormone-mediated Apoptotic Signaling Pathway Mitochondrial DNA Repair Cell Surface Receptor Signaling Pathway Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Apoptotic Signaling Pathway ER Overload Response Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Blood Coagulation Hemostasis Protein Oligomerization Response To Nutrient Levels Regulation Of Thymocyte Apoptotic Process Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior Response To Extracellular Stimulus Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Rhythmic Behavior Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process RRNA Transcription Response To Drug	Somatostatin Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Cyclic Compound Response To Estradiol Cellular Response To Lipid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Steroid Hormone Response To Peptide Response To Glucocorticoid Response To Corticosteroid Cellular Response To Hormone Stimulus Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Response To Lipid Response To Organic Cyclic Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Forebrain Development Cerebellum Development Metencephalon Development Regulation Of Cell Proliferation Hindbrain Development Response To Starvation Brain Development Cellular Response To Organic Substance Head Development Central Nervous System Development Response To Organic Substance Response To Nutrient Levels Response To Extracellular Stimulus Spermatogenesis Male Gamete Generation Cell Surface Receptor Signaling Pathway Digestion Gamete Generation Cellular Response To Stimulus Sexual Reproduction
Tagcloud ?		3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr1 sstr2 sstr4 sstr5 sstrs stimulating sw480 tcf wnt	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Difference) ?		3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr1 sstr2 sstr4 sstr5 sstrs stimulating sw480 tcf wnt	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Intersection) ?