BRAF and RAP1A

Number of citations of the paper that reports this interaction (PMID 9560161)
133

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		BRAF	RAP1A
Gene Name		B-Raf proto-oncogene, serine/threonine kinase	RAP1A, member of RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Plasma Membrane Neuron Projection Cell Body	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Protein Heterodimerization Activity	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Myeloid Progenitor Cell Differentiation Protein Phosphorylation Small GTPase Mediated Signal Transduction Synaptic Transmission Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-serine Phosphorylation Somatic Stem Cell Maintenance Cellular Response To Drug Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process CD4-positive, Alpha-beta T Cell Differentiation Positive T Cell Selection Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Positive Regulation Of Stress Fiber Assembly Response To CAMP Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Endothelial Cell Apoptotic Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways		Signalling to ERKs Prolonged ERK activation events Signalling by NGF Signaling by FGFR in disease NGF signalling via TRKA from the plasma membrane Spry regulation of FGF signaling CREB phosphorylation through the activation of Ras Signaling by FGFR ARMS-mediated activation Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signalling to p38 via RIT and RIN Frs2-mediated activation Transmission across Chemical Synapses Post NMDA receptor activation events Negative regulation of FGFR signaling	Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs		Sorafenib N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Vemurafenib Regorafenib Dabrafenib
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554)	Osteoporosis ( 20548944)
Protein-Protein Interactions		25 interactors: AKT1 BAD CCDC88A HRAS MAP2K1 MAP2K2 MAPK1 MRAS NEDD4L OIP5 PAK2 PRKACA PRKCE RAF1 RAP1A RAP1GAP RHEB RPS6KB2 SGK1 TERF1 YWHAB YWHAG YWHAH YWHAQ YWHAZ	41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C
Entrez ID		673	5906
HPRD ID		01264	01545
Ensembl ID		ENSG00000157764	ENSG00000116473
Uniprot IDs		P15056	A8KAH9 P62834
PDB IDs		1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4DBN 4E26 4E4X 4EHE 4EHG 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ	1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Regulation Of Cellular Localization Regulation Of Intracellular Transport Cell Death Death Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Activation Of MAPKK Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Cellular Response To Peptide Cellular Response To Insulin Stimulus Positive Regulation Of Phosphorylation Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Communication Insulin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity	Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation
Tagcloud ?		al araf augmentation craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?		al araf augmentation craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?