SPTA1 and EVL

Number of citations of the paper that reports this interaction (PMID 16336193)
6

Data Source:
HPRD (two hybrid)

		SPTA1	EVL
Gene Name		spectrin, alpha, erythrocytic 1	Enah/Vasp-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth	TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Other erythrocyte phenotypes ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		16 interactors: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 UBC VASP YWHAQ	27 interactors: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP FYB FYN HCK HTT LYN PFN2 POT1 PRPF40A SEMA6A SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17
Entrez ID		6708	51466
HPRD ID		01685	10942
Ensembl ID		ENSG00000163554	ENSG00000196405
Uniprot IDs		P02549	Q9UI08
PDB IDs		1OWA 3LBX
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Cell Development Axon Guidance Cell Morphogenesis Immune System Process Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Anatomical Structure Morphogenesis Axon Development Regulation Of Organelle Organization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament-based Process Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Cell Projection Organization Actin Polymerization Or Depolymerization Anatomical Structure Development Neuron Projection Development Regulation Of Cytoskeleton Organization Response To External Stimulus System Development Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Development Developmental Process Regulation Of Cellular Component Size Antigen Receptor-mediated Signaling Pathway Regulation Of Protein Complex Assembly Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Organ Development Neuron Differentiation Actin Filament Capping Locomotion Negative Regulation Of Actin Filament Depolymerization Immune Response-regulating Signaling Pathway Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization	Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Phagocytosis Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Process Chemotaxis Cell Projection Morphogenesis Cytoskeleton Organization Cell Part Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Neuron Development Locomotion Cell Morphogenesis Involved In Differentiation Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Cell Morphogenesis Neuron Projection Development Regulation Of Vesicle-mediated Transport Neuron Differentiation Cell Development Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cell Projection Organization Positive Regulation Of Organelle Organization Regulation Of Immune Response Actin Filament-based Process Negative Regulation Of Protein Complex Assembly Endocytosis Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Anatomical Structure Morphogenesis Regulation Of Immune System Process Actin Filament Organization Organelle Organization
Tagcloud ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes sptb ugt1a1	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes sptb ugt1a1	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?