SOX9 and EP300

Number of citations of the paper that reports this interaction (PMID 15623506)
42

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SOX9	EP300
Gene Name		SRY (sex determining region Y)-box 9	E1A binding protein p300
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Protein Complex Nuclear Transcription Factor Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase Activity Protein Binding Beta-catenin Binding Protein Kinase A Catalytic Subunit Binding Enhancer Binding BHLH Transcription Factor Binding Protein Heterodimerization Activity Pre-mRNA Intronic Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity, Transferring Acyl Groups Chromatin DNA Binding Activating Transcription Factor Binding Nuclear Hormone Receptor Binding Androgen Receptor Binding Pre-mRNA Intronic Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Epithelial To Mesenchymal Transition Tissue Homeostasis Positive Regulation Of Protein Phosphorylation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Immune System Process Heart Valve Development Heart Valve Morphogenesis Heart Valve Formation Endocardial Cushion Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Chondrocyte Hypertrophy Nucleosome Assembly Chromatin Remodeling Transcription From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Cytoskeleton Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Positive Regulation Of Cell Proliferation Male Gonad Development Regulation Of Cell Cycle Process Positive Regulation Of Epithelial Cell Migration Neural Crest Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Male Germ-line Sex Determination CAMP-mediated Signaling Regulation Of Cell Adhesion Extracellular Matrix Organization Negative Regulation Of Ossification Negative Regulation Of Bone Mineralization Prostate Gland Development Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Mammary Gland Development Notochord Development Otic Vesicle Formation Endocrine Pancreas Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Somatic Stem Cell Maintenance Intrahepatic Bile Duct Development Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Myoblast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Sertoli Cell Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Limb Bud Formation Retinal Rod Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Intestinal Epithelial Structure Maintenance Regulation Of Cell Proliferation Involved In Tissue Homeostasis Positive Regulation Of Cartilage Development Regulation Of Branching Involved In Lung Morphogenesis Morphogenesis Of A Branching Epithelium Negative Regulation Of Biomineral Tissue Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Interleukin-1 Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Induction Ureter Urothelium Development Ureter Smooth Muscle Cell Differentiation Ureter Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Male Gonad Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Response To Hypoxia Somitogenesis Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Internal Protein Amino Acid Acetylation Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Notch Signaling Pathway Nervous System Development Heart Development Skeletal Muscle Tissue Development Circadian Rhythm Organ Morphogenesis Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Lung Development Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Cellular Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Regulation Of Tubulin Deacetylation Regulation Of Cellular Response To Heat
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by Wnt NOTCH2 intracellular domain regulates transcription Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Pre-NOTCH Transcription and Translation RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by NOTCH1 PEST Domain Mutants in Cancer Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants PPARA activates gene expression Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Attenuation phase G2/M Transition HATs acetylate histones RORA activates circadian gene expression HSF1-dependent transactivation TRAF3-dependent IRF activation pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Pre-NOTCH Expression and Processing Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Cytosolic sensors of pathogen-associated DNA Cellular response to heat stress REV-ERBA represses gene expression Cell Cycle, Mitotic RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT TRAF6 mediated IRF7 activation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by WNT in cancer BMAL1:CLOCK,NPAS2 activates circadian gene expression Polo-like kinase mediated events
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Pulmonary function (interaction) ( 23284291) Pulmonary function decline ( 22424883) Thyroid hormone levels ( 23408906)	Crohn's disease ( 22936669)
Protein-Protein Interactions		14 interactors: ATP6V1H CREB1 CREB3L4 CREBBP EP300 HERC1 HSPA1A KPNB1 MAF MED12 NR5A1 RUNX2 SPEN TRAF2	344 interactors: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALX1 APEX1 AR ARNT ARNTL ARSF ASCL1 ASH2L ATF5 ATR BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDK1 CDK2 CDKN1A CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CLTC CNOT4 CNTN2 COPS2 COPS6 CREB1 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 E2F5 EGR1 EID1 EID2 ELF3 ELK1 EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO1 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B HAND2 HBP1 HDAC1 HDAC3 HDAC6 HERC1 HIF1A HIPK2 HIST1H1A HIST1H1D HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AB HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCM3AP MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MN1 MPG MRE11A MSH6 MSTO1 MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFKB1 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR2F2 NR4A1 NUP98 NUPR1 NUTM1 OLIG2 PAK2 PAX5 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POU3F2 PPARA PPARD PPARG PPP2R5C PRKCA PRKCB PRKCD PROX1 PTMA RAD23A RAD50 RAN RB1 RBM14 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 SATB1 SAV1 SENP3 SEPP1 SERTAD1 SET SETD1A SGCG SIRT1 SIRT2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SRC SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBE2D1 UBE2I UBQLN1 USF2 VPS18 WDR59 WDR82 XRCC6 YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF148 ZNF76 ZRANB2
Entrez ID		6662	2033
HPRD ID		06427	04078
Ensembl ID		ENSG00000125398	ENSG00000100393
Uniprot IDs		P48436	Q09472 Q7Z6C1
PDB IDs		1S9M 1SX9 4EUW	1L3E 1P4Q 2K8F 3BIY 3I3J 3IO2 3P57 3T92 4BHW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated Notch Signaling Pathway RNA Metabolic Process RNA Biosynthetic Process Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Gene Expression Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Heat DNA-templated Transcription, Initiation Cellular Response To Stimulus Signal Transduction Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Stabilization Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Signaling Rhythmic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Response To Heat Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Unfolded Protein	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Response To Organic Substance Cell Differentiation Regulation Of Cell Differentiation Developmental Process Regulation Of Cell Proliferation Anatomical Structure Development Multicellular Organismal Development Cellular Response To Organic Substance System Development Cellular Response To Stress Response To Stress Regulation Of Cellular Process Tissue Development
Tagcloud ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish	ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Difference) ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish	ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
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