BNIP2 and ARHGAP8

Number of citations of the paper that reports this interaction (PMID 12944407)
12

Data Source:
HPRD (in vivo, in vitro)

		BNIP2	ARHGAP8
Gene Name		BCL2/adenovirus E1B 19kDa interacting protein 2	Rho GTPase activating protein 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	GTPase Activator Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Rho GTPase Activator Activity Protein Binding
	Biological Process	Apoptotic Process Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Muscle Cell Differentiation	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		CDO in myogenesis Myogenesis	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			Electroencephalographic traits in alcoholism ( 22554406)
Protein-Protein Interactions		13 interactors: ARHGAP1 ARHGAP8 BCL2 BNIPL CDC42 CREB3 FATE1 FGFR1 FRK KLC1 MYO5B NCBP1 UPK1B	4 interactors: BNIP2 CTTN RHOA SH3GL1
Entrez ID		663	23779
HPRD ID		04481	06448
Ensembl ID		ENSG00000140299	ENSG00000241484
Uniprot IDs		J3KN59 Q12982	A6ZJ79 P85298 Q6PJW1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Heterodimerization Activity Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Gland Morphogenesis Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Hair Follicle Morphogenesis Regulation Of Growth Epidermis Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Signal Transduction Salivary Gland Development Epidermis Development Skin Morphogenesis Neural Nucleus Development Cell Fate Commitment Exocrine System Development Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cellular PH Reduction Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cellular Metabolic Process Midbrain Development Positive Regulation Of Muscle Cell Differentiation Adherens Junction Organization Regulation Of Cell Cycle Hair Follicle Development Stress Granule Disassembly Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Lateral Mesodermal Cell Fate Specification Release From Viral Latency Hair Cycle Process Renal System Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-serine Phosphorylation	Regulation Of Neuron Differentiation Nervous System Development Regulation Of Neurogenesis Regulation Of Cell Development Regulation Of Axonogenesis Cell Junction Assembly Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Skeletal Muscle Satellite Cell Migration Apolipoprotein A-I-mediated Signaling Pathway System Development Positive Regulation Of Cellular Component Biogenesis Cleavage Furrow Formation Generation Of Neurons Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Dendritic Spine Maintenance Neurogenesis Regulation Of Actin Cytoskeleton Organization Regulation Of Neuron Projection Development Substrate-dependent Cell Migration, Cell Extension Multicellular Organismal Development Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Neurogenesis Anatomical Structure Development Microtubule Cytoskeleton Organization Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Development Ossification Involved In Bone Maturation Developmental Process Bone Maturation Negative Chemotaxis Mitotic Spindle Assembly Dendritic Spine Organization Actin Cytoskeleton Organization Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Osteoblast Proliferation Cellular Component Maintenance Neuron Projection Morphogenesis Actin Filament-based Process Endocytosis Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Substrate-dependent Cell Migration Microtubule-based Process
Tagcloud ?		activator antiapoptotic attenuated bcl blocks cleavage cytotoxicity deacetylase imply inhibits intensified mediate mpp nad neuroprotective parp participates phenylpyridinium possibly resveratrol sh shrna sirna sirt1 sirtuin sy5y transfected transfection xl
Tagcloud (Difference) ?		activator antiapoptotic attenuated bcl blocks cleavage cytotoxicity deacetylase imply inhibits intensified mediate mpp nad neuroprotective parp participates phenylpyridinium possibly resveratrol sh shrna sirna sirt1 sirtuin sy5y transfected transfection xl
Tagcloud (Intersection) ?