BMP6 and BMPER

Number of citations of the paper that reports this interaction (PMID 12897139)
42

Data Source:
HPRD (in vivo)

		BMP6	BMPER
Gene Name		bone morphogenetic protein 6	BMP binding endothelial regulator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane-bounded Vesicle	Extracellular Space
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Response To Iron Ion Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Cartilage Development Response To Glucocorticoid SMAD Protein Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Aldosterone Secretion	Ureteric Bud Development Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Endothelial Cell Migration Negative Regulation Of BMP Signaling Pathway Endothelial Cell Activation Endothelial Cell Differentiation Inner Ear Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666)
Protein-Protein Interactions		9 interactors: ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1	3 interactors: BMP2 BMP4 BMP6
Entrez ID		654	168667
HPRD ID		00211	16368
Ensembl ID		ENSG00000153162	ENSG00000164619
Uniprot IDs		B4DUF7 P22004 Q4VBA3	Q8N8U9
PDB IDs		2QCW 2R52 2R53
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Tissue Development Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cartilage Development Regulation Of Ossification Pattern Specification Process Organ Development Regulation Of Bone Mineralization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Skeletal System Development Sex Differentiation Tube Development Anatomical Structure Morphogenesis Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Cell Differentiation System Development Regulation Of Cell Differentiation Regulation Of Signal Transduction Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Epithelium Development Regulation Of Signaling Anatomical Structure Development Mullerian Duct Regression Developmental Process Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Organ Morphogenesis Anatomical Structure Regression Mesoderm Development Embryo Development Cellular Response To BMP Stimulus Single Organism Reproductive Process Male Sex Differentiation Gastrulation Positive Regulation Of Signal Transduction Limb Development Reproductive Process Protein Phosphorylation	Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Glandular Epithelial Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Endothelial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development BMP Signaling Pathway Involved In Heart Induction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of Endothelial Cell Proliferation Regulation Of Cartilage Development Positive Regulation Of Ossification BMP Signaling Pathway Involved In Heart Development Regulation Of Osteoblast Differentiation Osteoblast Differentiation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Regulation Of Ossification Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Bone Development Regulation Of Odontogenesis Of Dentin-containing Tooth Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Positive Regulation Of Endothelial Cell Differentiation Mesenchymal Cell Proliferation Positive Regulation Of DNA-dependent DNA Replication Type B Pancreatic Cell Development Ossification Regulation Of Endothelial Cell Differentiation Regulation Of Epithelial Cell Proliferation Kidney Development Regulation Of Transcription Involved In Cell Fate Commitment Type B Pancreatic Cell Differentiation Positive Regulation Of Neuron Differentiation Renal System Development Enteroendocrine Cell Differentiation Forebrain Regionalization Regulation Of Hormone Biosynthetic Process Regulation Of Odontogenesis Urogenital System Development Glandular Epithelial Cell Development Regulation Of Heart Morphogenesis Positive Regulation Of Neurogenesis Regulation Of Hormone Metabolic Process Organ Induction
Tagcloud ?		anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness	acts array biology bmp4 coreceptor endocytic endocytosis enhances evidenced fine introduce ldl lrp1 mediate member modulates modulators morphogenetic observations rationale regulator sink smad1 spatial tune unlike vasculogenic zebrafish
Tagcloud (Difference) ?		anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness	acts array biology bmp4 coreceptor endocytic endocytosis enhances evidenced fine introduce ldl lrp1 mediate member modulates modulators morphogenetic observations rationale regulator sink smad1 spatial tune unlike vasculogenic zebrafish
Tagcloud (Intersection) ?