PYCRL and LBP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PYCRL	LBP
Gene Name		pyrroline-5-carboxylate reductase-like	lipopolysaccharide binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Extracellular Region Extracellular Space Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity	Lipopolysaccharide Binding Receptor Binding Protein Binding Lipoteichoic Acid Binding
	Biological Process	Oxidation-reduction Process L-proline Biosynthetic Process	Toll-like Receptor Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Innate Immune System
Drugs
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		3 interactors: LBP PRMT6 SDCBP	19 interactors: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 IRF6 PRDX4 PSMA3 PYCRL RPS21 SETD1A SMAD3 TRA2A TSC22D4
Entrez ID		65263	3929
HPRD ID		15196	07175
Ensembl ID		ENSG00000104524	ENSG00000129988
Uniprot IDs		Q53H96	P18428 Q8TCF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Histone H3-R2 Methylation Lipopolysaccharide Transport Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Respiratory Burst Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Opsonization Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Macrophage Activation Positive Regulation Of Toll-like Receptor Signaling Pathway Histone H4-R3 Methylation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Chemotaxis Peptidyl-arginine N-methylation Leukocyte Migration Involved In Inflammatory Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Histone Arginine Methylation Peptidyl-arginine Methylation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Organelle Assembly Regulation Of Macrophage Activation Positive Regulation Of Granulocyte Chemotaxis Negative Regulation Of Growth Of Symbiont In Host Detection Of Biotic Stimulus Cell Migration Regulation Of Neutrophil Chemotaxis Macrophage Activation Regulation Of Neutrophil Migration Positive Regulation Of Interleukin-8 Production Cell Motility Defense Response To Gram-negative Bacterium Regulation Of Granulocyte Chemotaxis Substrate-dependent Cell Migration Lipopolysaccharide-mediated Signaling Pathway Acute-phase Response Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Chemokine Production Carbohydrate Derivative Transport Cellular Defense Response	Immune System Process Immune Response Regulation Of Interleukin-1 Beta Production Regulation Of Cell Proliferation Humoral Immune Response Protein Stabilization Response To Stress Regulation Of Protein Stability Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Immune System Process Posttranscriptional Regulation Of Gene Expression Regulation Of Immune Response Positive Regulation Of Stress Fiber Assembly Response To Stimulus Negative Regulation Of Protein Metabolic Process Positive Regulation Of Actin Filament Bundle Assembly Gene Expression Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Growth Of Symbiont On Or Near Host Surface Regulation Of Protein Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production I-kappaB Kinase/NF-kappaB Signaling Cell Cycle Process Regulation Of Stress Fiber Assembly Regulation Of Inflammatory Response Negative Regulation Of Cell Proliferation Regulation Of Opsonization Intracellular Sequestering Of Iron Ion Negative Regulation Of Interleukin-1 Beta Secretion Sister Chromatid Biorientation Response To Other Organism Positive Regulation Of Protein Metabolic Process Epithelial Cell Proliferation Intracellular Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Male Germ Cell Proliferation Evasion Or Tolerance Of Host Defenses By Virus Response To Biotic Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Negative Regulation Of Inflammatory Response
Tagcloud ?			adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals
Tagcloud (Difference) ?			adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals
Tagcloud (Intersection) ?