PLEKHG2 and GNG2

Number of citations of the paper that reports this interaction (PMID 18045877)
11

Data Source:
BioGRID (pull down)

		PLEKHG2	GNG2
Gene Name		pleckstrin homology domain containing, family G (with RhoGef domain) member 2	guanine nucleotide binding protein (G protein), gamma 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity	Signal Transducer Activity G-protein Beta-subunit Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs			Halothane
Diseases
GWAS			Non-melanoma skin cancer ( 23548203)
Protein-Protein Interactions		8 interactors: ACTN3 APP CDC42 GNB1 GNG2 RAC1 RHOA XRN1	15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R
Entrez ID		64857	54331
HPRD ID		15148	16234
Ensembl ID		ENSG00000090924	ENSG00000186469
Uniprot IDs		E7ESZ3 Q9H7P9	P59768
PDB IDs			4KFM
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell-cell Junction Organization Cell Activation Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Axonogenesis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Positive Regulation Of Cell Morphogenesis Involved In Differentiation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Small GTPase Mediated Signal Transduction Cellular Response To Catecholamine Stimulus Neuron Projection Morphogenesis Actin Filament-based Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Cycle Process Movement Of Cell Or Subcellular Component Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Involved In Differentiation Dopamine Receptor Signaling Pathway Substantia Nigra Development Brain Development Cellular Response To Glucagon Stimulus Positive Regulation Of Cytokinesis Head Development Positive Regulation Of Cell Projection Organization Neuron Projection Development Positive Regulation Of Cell Cycle Positive Regulation Of Stress Fiber Assembly Cellular Response To Fatty Acid Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Response To External Stimulus Regulation Of Phosphatidylinositol 3-kinase Activity Response To Glucagon	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure
Tagcloud ?		abl1 candidates cdc42 constitutively csrc cytoskeletal ephrinb2 flj00018 gbetagamma gtp guanine hek293 heterotrimeric homology kinse mutagenesis partner phosphorylated pik3r3 rac reorganization rho rhogef sh2 substitution throughput turn tyr489 tyrosine	abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Difference) ?		abl1 candidates cdc42 constitutively csrc cytoskeletal ephrinb2 flj00018 gbetagamma gtp guanine hek293 heterotrimeric homology kinse mutagenesis partner phosphorylated pik3r3 rac reorganization rho rhogef sh2 substitution throughput turn tyr489 tyrosine	abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Intersection) ?