ITSN1 and PREX1

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN1	PREX1
Gene Name		intersectin 1 (SH3 domain protein)	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse	Cytoplasm Cytosol Plasma Membrane Growth Cone Dendritic Shaft Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding	Rho Guanyl-nucleotide Exchange Factor Activity Rho GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Superoxide Metabolic Process G-protein Coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Intracellular Signal Transduction Neutrophil Activation Regulation Of Dendrite Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Nephrotic syndrome (acquired) ( 21441931) Tonometry ( 17903302)
Protein-Protein Interactions		82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2	3 interactors: ITSN1 MTOR PPP1CA
Entrez ID		6453	57580
HPRD ID		03898	06066
Ensembl ID		ENSG00000205726	ENSG00000124126
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	Q8TCU6
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM	3QIK
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis	Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Glucose Metabolic Process Regulation Of Protein Kinase B Signaling Regulation Of Carbohydrate Metabolic Process Regulation Of Carbohydrate Utilization Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Rho GTPase Activity Response To External Stimulus Cellular Response To Organic Substance Regulation Of Rho Protein Signal Transduction Negative Regulation Of NFAT Protein Import Into Nucleus Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Response To Organic Substance Negative Regulation Of Macroautophagy Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Size Positive Regulation Of Programmed Cell Death Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Cell Death Positive Regulation Of Lamellipodium Organization Regulation Of Response To Food Regulation Of Ras Protein Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Triglyceride Catabolic Process Regulation Of Rac GTPase Activity TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Entrainment Of Circadian Clock By Photoperiod Regulation Of Lamellipodium Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat
Tagcloud ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	10a aza bisulfite cpg demethylating demethylation deoxycitidine dissecting dissemination distinctive erbb essentially gef hypermethylation hypomethylation inversely island kb luminal pyrosequencing rac restores rho subtype tcga trichostatin undetectable vav3
Tagcloud (Difference) ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	10a aza bisulfite cpg demethylating demethylation deoxycitidine dissecting dissemination distinctive erbb essentially gef hypermethylation hypomethylation inversely island kb luminal pyrosequencing rac restores rho subtype tcga trichostatin undetectable vav3
Tagcloud (Intersection) ?