CXCL12 and CXCR4

Number of citations of the paper that reports this interaction (PMID 8752281)
310

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vivo, in vitro)

		CXCL12	CXCR4
Gene Name		chemokine (C-X-C motif) ligand 12	chemokine (C-X-C motif) receptor 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Growth Cone Cell Leading Edge Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding	Virus Receptor Activity Actin Binding G-protein Coupled Receptor Activity Protein Binding Coreceptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding Ubiquitin Binding
	Biological Process	Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Cell Adhesion Signal Transduction G-protein Coupled Receptor Signaling Pathway Germ Cell Development Blood Circulation Motor Neuron Axon Guidance Regulation Of Actin Polymerization Or Depolymerization Adult Locomotory Behavior Germ Cell Migration Response To Radiation Response To Heat Response To Mechanical Stimulus Response To Virus Telencephalon Cell Migration Organ Regeneration Positive Regulation Of Dopamine Secretion T Cell Proliferation Response To Peptide Hormone Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Induction Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Myoblast Fusion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of T Cell Migration	Activation Of MAPK Activity Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Dendritic Cell Chemotaxis Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Germ Cell Development Brain Development Motor Neuron Axon Guidance Germ Cell Migration Response To Virus Viral Process Calcium-mediated Signaling Entry Into Host Cell Regulation Of Cell Migration T Cell Proliferation Neutrophil Activation Myelin Maintenance Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Chemotaxis Neural Precursor Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signaling by ERBB4 GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Nuclear signaling by ERBB4 Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs		Tinzaparin	Framycetin Plerixafor
Diseases
GWAS		Coronary heart disease ( 17634449 21378990) Myocardial infarction (early onset) ( 19198609) Schizophrenia ( 23212062)	Multiple sclerosis ( 19525953) Telomere length ( 20421499)
Protein-Protein Interactions		10 interactors: CD4 CTSG CXCR4 DAZAP2 DPP4 ELANE FN1 MMP2 PF4 VCAN	32 interactors: ADRBK2 ARRB2 ATP13A2 CCR5 CD4 CTSG CXCL12 DPP4 ELANE GNA13 GNAI1 HLA-C HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		6387	7852
HPRD ID		02904	01217
Ensembl ID		ENSG00000107562	ENSG00000121966
Uniprot IDs		H7BYN8 P48061	P61073
PDB IDs		1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2NWG 2SDF 3GV3 3HP3 4LMQ	2K03 2K04 2K05 3ODU 3OE0 3OE6 3OE8 3OE9
Enriched GO Terms of Interacting Partners?		Locomotion Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Movement Of Cell Or Subcellular Component Cell Migration Positive Regulation Of Immune System Process Cell Motility Leukocyte Migration Response To Stress Immune System Process Regulation Of Immune System Process Cell Activation Defense Response Response To Other Organism Killing By Host Of Symbiont Cells Response To Biotic Stimulus Inflammatory Response Response To External Stimulus Regulation Of Chemotaxis Response To Bacterium Neutrophil Mediated Immunity Cell Adhesion Killing Of Cells Of Other Organism Regulation Of Behavior Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Positive Regulation Of Immune Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Endodermal Cell Differentiation Response To Fungus Entry Into Host Cell T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Intracellular Signal Transduction Response To Hypoxia Response To Lipopolysaccharide Leukocyte Cell-cell Adhesion Endoderm Formation Regulation Of Immune Response Cardiovascular System Development Homotypic Cell-cell Adhesion Angiogenesis Response To Molecule Of Bacterial Origin Chemokine-mediated Signaling Pathway Collagen Catabolic Process	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Immune Response Regulation Of Immune System Process Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Stress Defense Response JAK-STAT Cascade Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Innate Immune Response Regulation Of Cell-cell Adhesion Locomotion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Regulation Of Type I Interferon-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Response To Peptide Hormone Regulation Of Cell Adhesion Innate Immune Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Peptide Signaling Movement Of Cell Or Subcellular Component Response To Type I Interferon Cell Migration Positive Regulation Of Cell Adhesion Cell Communication Response To External Stimulus Cell Activation Positive Regulation Of Immune System Process Interferon-gamma-mediated Signaling Pathway Cell Motility Response To Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Interferon-gamma Regulation Of Signal Transduction Signal Transduction Cellular Response To Organic Substance Response To Interferon-gamma
Tagcloud ?		adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Difference) ?		adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Intersection) ?