CCL15 and CCR3

Number of citations of the paper that reports this interaction (PMID 9346309)
9

Data Source:
HPRD (in vivo)

		CCL15	CCR3
Gene Name		chemokine (C-C motif) ligand 15	chemokine (C-C motif) receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Chemokine Activity Heparin Binding Chemoattractant Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity
	Biological Process	Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Signal Transduction Cell-cell Signaling Positive Chemotaxis Cell Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CCR1 CCR3	19 interactors: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6359	1232
HPRD ID		03232	03167
Ensembl ID		ENSG00000267596	ENSG00000183625
Uniprot IDs		Q16663	P51677 Q8TDP4 Q8TDP5
PDB IDs		2HCC
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Cytokine Stimulus Chemotaxis Positive Regulation Of Monocyte Chemotaxis Cellular Homeostasis Response To Cytokine Dendritic Cell Chemotaxis Regulation Of Monocyte Chemotaxis Chemical Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Dendritic Cell Migration Positive Regulation Of Osteoclast Differentiation G-protein Coupled Receptor Signaling Pathway Cell Adhesion Locomotion Defense Response Homeostatic Process Positive Regulation Of Myeloid Leukocyte Differentiation Cellular Defense Response Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis Regulation Of Osteoclast Differentiation Response To External Stimulus Regulation Of Bone Mineralization Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Ossification Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Migration Positive Regulation Of Calcium Ion Transport Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Leukocyte Migration Positive Regulation Of Angiogenesis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway	Cell Chemotaxis Cell Migration Cell Motility Chemotaxis Locomotion Immune Response Movement Of Cell Or Subcellular Component Inflammatory Response Response To External Stimulus Immune System Process Leukocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Leukocyte Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Eosinophil Chemotaxis Positive Regulation Of Leukocyte Migration Defense Response Eosinophil Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Component Movement Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Granulocyte Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Lymphocyte Migration Cellular Metal Ion Homeostasis Regulation Of Cell Shape Cellular Cation Homeostasis Cell-cell Signaling Cellular Ion Homeostasis Positive Regulation Of Calcium Ion Transport Metal Ion Homeostasis Regulation Of Behavior Response To Other Organism Lymphocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Response To Biotic Stimulus T Cell Migration Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Immune System Process
Tagcloud ?		activates adhesion adhesivity ccr1 chemoattractant chemokine chemokines ecs hypoxia icam immunoprecipitation jak leukocytes member monocyte monocytes predominantly pretreatment reoxygenation reporter shear stat3 static stimulates treating upregulated upregulating upregulation	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		activates adhesion adhesivity ccr1 chemokine chemokines ecs hypoxia icam immunoprecipitation jak leukocytes member monocyte monocytes predominantly pretreatment reoxygenation reporter shear stat3 static stimulates treating upregulated upregulating upregulation	basophil basophils c5a ccr2 chains chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?		chemoattractant