CCL13 and MMP3

Number of citations of the paper that reports this interaction (PMID 12149192)
92

Data Source:
HPRD (in vitro)

		CCL13	MMP3
Gene Name		chemokine (C-C motif) ligand 13	matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Mitochondrion Cytosol
	Molecular Function	Receptor Binding Chemokine Activity	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Eosinophil Chemotaxis	Proteolysis Negative Regulation Of Hydrogen Peroxide Metabolic Process Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Negative Regulation Of Protein Kinase B Signaling Cellular Response To Amino Acid Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Oxidative Stress-induced Cell Death
Pathways			Signaling by GPCR EGFR Transactivation by Gastrin Collagen formation Collagen degradation Gastrin-CREB signalling pathway via PKC and MAPK Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide 3-Methylpyridine A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide R-2-{[4\'-Methoxy-(1,1\'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID [2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide 3-[(4\'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)	Alzheimer's disease ( 22832961)
Protein-Protein Interactions		8 interactors: ACKR2 ACKR4 APP CCR3 CCR5 HNRNPH3 MMP1 MMP3	18 interactors: ACAN BCAN CCL13 CCL2 CCL7 CCL8 DCN HAPLN1 IGFBP3 MEOX2 PLG SERPINE1 SPOCK1 SPOCK3 SPP1 TIMP1 TIMP3 TNFSF11
Entrez ID		6357	4314
HPRD ID		03230	01703
Ensembl ID		ENSG00000181374	ENSG00000149968
Uniprot IDs		Q99616	P08254
PDB IDs		2RA4	1B3D 1B8Y 1BIW 1BM6 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1M1W 1OO9 1QIA 1QIC 1SLM 1SLN 1UEA 1UMS 1UMT 1USN 2D1O 2JNP 2JT5 2JT6 2SRT 2USN 3OHL 3OHO 3USN 4DPE 4G9L 4JA1
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Oligomerization Cellular Response To Cytokine Stimulus Regulation Of Protein Oligomerization Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To External Stimulus Cellular Response To Organic Substance Cellular Defense Response Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Response To Stress Cellular Metal Ion Homeostasis Immune System Process Inflammatory Response Collagen Metabolic Process G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Multicellular Organismal Macromolecule Metabolic Process Cellular Ion Homeostasis Multicellular Organismal Metabolic Process Metal Ion Homeostasis Extracellular Matrix Disassembly Immune Response Response To Organic Substance Cellular Chemical Homeostasis Defense Response Viral Process Synaptic Growth At Neuromuscular Junction Ion Homeostasis Collateral Sprouting In Absence Of Injury Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Surface Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Cytosolic Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Cell Chemotaxis Leukocyte Migration Leukocyte Chemotaxis Cell Migration Granulocyte Chemotaxis Cell Motility Monocyte Chemotaxis Proteoglycan Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Locomotion Calcium Ion Homeostasis Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Proteolysis Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Processing Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Glycosaminoglycan Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Chondroitin Sulfate Metabolic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Peptidase Activity Inflammatory Response Regulation Of Cell-substrate Adhesion Developmental Process Negative Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Cell Motility Negative Regulation Of Cellular Protein Metabolic Process Metal Ion Homeostasis Regulation Of Catalytic Activity Platelet Degranulation Eosinophil Migration Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Negative Regulation Of Cellular Component Movement Response To External Stimulus Negative Regulation Of Fibrinolysis Positive Regulation Of Monocyte Chemotaxis Dermatan Sulfate Biosynthetic Process Negative Regulation Of Locomotion
Tagcloud ?		3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous	6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc intra metalloproteinases mmp13 mmps nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley
Tagcloud (Difference) ?		3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous	6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc intra metalloproteinases mmp13 mmps nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley
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