CCL8 and CCR5

Number of citations of the paper that reports this interaction (PMID 10477718)
47

Data Source:
HPRD (in vivo)

		CCL8	CCR5
Gene Name		chemokine (C-C motif) ligand 8	chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Protein Kinase Activity Chemokine Activity Heparin Binding Phospholipase Activator Activity	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Catalytic Activity Cell Chemotaxis	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Maraviroc
Diseases
GWAS		Crohn's disease ( 22412388)	Celiac disease ( 20190752)
Protein-Protein Interactions		8 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR5 MMP3 VCAN	41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK
Entrez ID		6355	1234
HPRD ID		03791	03223
Ensembl ID		ENSG00000108700	ENSG00000160791
Uniprot IDs		P80075	A0A502 P51681 Q38L21
PDB IDs		1ESR	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Inflammatory Response Cellular Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Chemotaxis Locomotion Response To Organic Substance Dendritic Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To External Stimulus Cellular Defense Response Response To Stress Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Immune Response Leukocyte Chemotaxis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Chemotaxis Signal Transduction Cell Migration Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Motility Signaling Response To Stimulus Regulation Of Hydrogen Peroxide Metabolic Process Cell Communication Immune System Process Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process	Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus
Tagcloud ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		3kda attenuation blockage cd44 conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemotactic cxc cxcr1 eotaxin hcc2 mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?		chemokines leukocytes