CCL2 and ACKR4

Number of citations of the paper that reports this interaction (PMID 10734104)
12

Data Source:
HPRD (in vitro)

		CCL2	ACKR4
Gene Name		chemokine (C-C motif) ligand 2	atypical chemokine receptor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Endocytic Vesicle Dendrite Perikaryon Axon Terminus C-fiber Synapse Perinuclear Region Of Cytoplasm	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome
	Molecular Function	Protein Kinase Activity Receptor Binding Chemokine Activity Heparin Binding CCR2 Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding Chemokine Binding
	Biological Process	MAPK Cascade Angiogenesis Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Endothelial Cell Proliferation Leukocyte Migration Involved In Inflammatory Response Monocyte Chemotaxis Positive Regulation Of Cellular Extravasation Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Humoral Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger JAK-STAT Cascade Aging Regulation Of Cell Shape Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Bacterium Organ Morphogenesis Response To Gamma Radiation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Response To Activity Negative Regulation Of Angiogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Cellular Homeostasis Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Lipopolysaccharide-mediated Signaling Pathway Response To Progesterone Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin B3 Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Cellular Response To Drug Cellular Response To Macrophage Colony-stimulating Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Response To Amino Acid Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Response To Antibiotic Vascular Endothelial Growth Factor Receptor Signaling Pathway Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Maternal Process Involved In Female Pregnancy Maternal Process Involved In Parturition Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To ATP Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Calcium Ion Import Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Receptor-mediated Endocytosis Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) ATF4 activates genes GPCR ligand binding Metabolic disorders of biological oxidation enzymes Peptide ligand-binding receptors Chemokine receptors bind chemokines PERK regulates gene expression Unfolded Protein Response (UPR)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Mimosine Danazol
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		11 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 MMP1 MMP3 MMP8 VCAN	11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6347	51554
HPRD ID		01149	07298
Ensembl ID		ENSG00000108691	ENSG00000129048
Uniprot IDs		P13500	Q9NPB9
PDB IDs		1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Locomotion Inflammatory Response Chemotaxis G-protein Coupled Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Response To Organic Substance Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Defense Response Extracellular Matrix Organization Extracellular Structure Organization Dendritic Cell Chemotaxis Response To Stress Cellular Metal Ion Homeostasis Positive Regulation Of Protein Oligomerization Cellular Cation Homeostasis Cellular Ion Homeostasis Neutrophil Activation Metal Ion Homeostasis Dendritic Cell Migration Response To External Stimulus Cellular Chemical Homeostasis Regulation Of Protein Oligomerization Ion Homeostasis Leukocyte Migration Cell Surface Receptor Signaling Pathway Immune Response Immune System Process Cellular Homeostasis Cellular Defense Response Cell Migration Chemical Homeostasis Receptor-mediated Endocytosis Cell Motility Leukocyte Chemotaxis Viral Process Response To Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Cell Chemotaxis Leukocyte Chemotaxis Leukocyte Migration Inflammatory Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Regulation Of Leukocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Cell Migration Cell Motility Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Homeostasis Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Locomotion Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response Positive Regulation Of Chemotaxis Chemical Homeostasis Positive Regulation Of Behavior Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Regulation Of Cell Migration Positive Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Response To External Stimulus Regulation Of Cellular Component Movement Regulation Of Behavior Homeostatic Process Immune System Process Response To Stress Regulation Of Granulocyte Chemotaxis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Cell-cell Adhesion
Tagcloud ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit
Tagcloud (Difference) ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit
Tagcloud (Intersection) ?