SAA1 and COL4A1

Number of citations of the paper that reports this interaction (PMID 8995276)
1

Data Source:
HPRD (in vitro)

		SAA1	COL4A1
Gene Name		serum amyloid A1	collagen, type IV, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region High-density Lipoprotein Particle Extracellular Vesicular Exosome Endocytic Vesicle Lumen	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	G-protein Coupled Receptor Binding Heparin Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding
	Biological Process	Receptor-mediated Endocytosis Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Formyl peptide receptors bind formyl peptides and many other ligands DEx/H-box helicases activate type I IFN and inflammatory cytokines production Amyloids Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Peptide ligand-binding receptors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane G alpha (i) signalling events Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA GPCR ligand binding MyD88-independent cascade G alpha (q) signalling events Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways GPCR downstream signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRAF6 mediated NF-kB activation Scavenging by Class B Receptors TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Amyloid A Levels ( 21124955)	Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 LAMA1 VIMP VKORC1	27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1
Entrez ID		6288	1282
HPRD ID		00097	00359
Ensembl ID		ENSG00000173432	ENSG00000187498
Uniprot IDs		P0DJI8	P02462
PDB IDs			1LI1
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Retinal Blood Vessel Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Retina Vasculature Morphogenesis In Camera-type Eye Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Retina Vasculature Development In Camera-type Eye Generation Of Neurons Neurogenesis Catabolic Process Cell Development Renal System Development Glomerulus Development Response To Stimulus Urogenital System Development Blood Vessel Morphogenesis Negative Regulation Of Angiogenesis Regulation Of Nitric Oxide Metabolic Process Nervous System Development Anatomical Structure Morphogenesis Blood Vessel Development Vasculature Development System Development Endothelial Cell Apoptotic Process Nephron Development Multicellular Organismal Development Organ Development Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Difference) ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Intersection) ?