RPLP0 and PAFAH1B2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RPLP0	PAFAH1B2
Gene Name		ribosomal protein, large, P0	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome	Nucleolus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosome Biogenesis Cellular Protein Metabolic Process	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		11 interactors: CCNDBP1 CSNK2A1 ERG GAS7 KRI1 PAFAH1B2 PPM1A PRPF40A SMAD3 STAU1 YWHAQ	14 interactors: ACIN1 ASF1A CCT3 PAFAH1B1 PAFAH1B3 PARK2 PINX1 PPP1R12C REXO1 RPLP0 SLA SNUPN TIMM50 ZFP36L1
Entrez ID		6175	5049
HPRD ID		01610	03940
Ensembl ID		ENSG00000089157	ENSG00000168092
Uniprot IDs		P05388 Q3B7A4	P68402
PDB IDs		3J39 3J3B	1VYH
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle Arrest Positive Regulation Of Wnt Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Potassium Ion Export Cell Cycle Process Regulation Of Transcription Factor Import Into Nucleus Regulation Of Intracellular Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Morphogenesis Regulation Of Heart Rate By Hormone Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Process Negative Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Cell Shape Negative Regulation Of SMAD Protein Complex Assembly Regulation Of Extracellular Matrix Assembly Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Import Into Nucleus Regulation Of Establishment Of Protein Localization Primary MiRNA Processing Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Nucleocytoplasmic Transport N-terminal Protein Myristoylation Regulation Of Transcription, DNA-templated Regulation Of Protein Localization Negative Regulation Of Mitotic Cell Cycle Regulation Of Nucleic Acid-templated Transcription	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Organelle Negative Regulation Of JNK Cascade MRNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Cellular Localization RNA Import Into Nucleus Positive Regulation Of Protein Linear Polyubiquitination Proepicardium Development Regulation Of Cytokine-mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Establishment Of Centrosome Localization Adult Locomotory Behavior Catabolic Process Neuromuscular Process Cellular Component Assembly Protein Localization Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Chromosome Condensation Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Platelet Activating Factor Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Single Organism Reproductive Process Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of MAPK Cascade MRNA Catabolic Process Regulation Of JNK Cascade Adult Behavior Positive Regulation Of Monocyte Differentiation
Tagcloud ?		3months 60s brains brdu bromodeoxyuridine cacybp calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside pk postnatal proteomic pyruvate spots tk transketolase ts1cje	1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Difference) ?		3months 60s brains brdu bromodeoxyuridine cacybp calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside pk postnatal proteomic pyruvate spots tk transketolase ts1cje	1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
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