RPL22 and IL7R

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		RPL22	IL7R
Gene Name		ribosomal protein L22	interleukin 7 receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Heparin Binding Poly(A) RNA Binding	Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Alpha-beta T Cell Differentiation	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		7 interactors: CALM1 CDC42 CSE1L IL7R MAPK14 NSFL1C SRPK2	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		6146	3575
HPRD ID		01602	00893
Ensembl ID		ENSG00000116251	ENSG00000168685
Uniprot IDs		P35268	D6RGV2 D9N160 P16871
PDB IDs		3J3B	3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response Innate Immune Response Substantia Nigra Development Regulation Of Immune Response Leukocyte Differentiation Angiogenesis Neural Nucleus Development Immune System Process Regulation Of Cytokinesis Positive Regulation Of Neuron Apoptotic Process Blood Coagulation Blood Vessel Morphogenesis Hemostasis Regulation Of Intracellular Transport Positive Regulation Of Neuron Death Golgi Organization Immune Response-regulating Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Midbrain Development Regulation Of Immune System Process Positive Regulation Of Kinase Activity Growth Nuclear Speck Organization P38MAPK Cascade Defense Response Blood Vessel Development Vasculature Development Positive Regulation Of Transferase Activity Regulation Of Body Fluid Levels Myeloid Leukocyte Differentiation Wound Healing Positive Regulation Of Gene Expression Nucleus Organization Interleukin-7-mediated Signaling Pathway Positive Regulation Of Hair Follicle Cell Proliferation Hemopoiesis Organelle Organization Cellular Response To Radiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Glucose Metabolic Process Response To Wounding Immune System Development Submandibular Salivary Gland Formation Actin Filament Branching Regulation Of Muscle Cell Differentiation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Transport	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		apocytochrome infa l20 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl20 rpl23 rpl33 rpoa rps11 rps12 rps18 rps3 rps8 secx ugg	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		apocytochrome infa l20 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl20 rpl23 rpl33 rpoa rps11 rps12 rps18 rps3 rps8 secx ugg	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?