RPL8 and NUDT3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RPL8	NUDT3
Gene Name		ribosomal protein L8	nudix (nucleoside diphosphate linked moiety X)-type motif 3
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Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit	Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome RRNA Binding Poly(A) RNA Binding	Magnesium Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Synthesis of pyrophosphates in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS			Body mass index ( 20935630) Height ( 19893584)
Protein-Protein Interactions		12 interactors: ARIH2 ARL15 C11orf49 CHDH DPH3 DUSP23 FAM188A FGFR3 IL7R NUDT3 ST3GAL3 UPF2	36 interactors: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1
Entrez ID		6132	11165
HPRD ID		16044	14849
Ensembl ID		ENSG00000161016
Uniprot IDs		P62917	O95989
PDB IDs		3J3B	2FVV 2Q9P
Enriched GO Terms of Interacting Partners?		Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Interleukin-7-mediated Signaling Pathway Glycine Betaine Biosynthetic Process From Choline Growth	Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Cellular Metabolic Process Protein Targeting Intracellular Transport Protein Localization To Organelle Cellular Localization Cellular Protein Localization Translational Elongation Establishment Of Protein Localization To Organelle Catabolic Process Protein Localization To Membrane Protein Localization Intracellular Protein Transport Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cellular Process Establishment Of Localization In Cell Protein Targeting To ER Cytoplasmic Transport Aromatic Compound Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Transport Protein Localization To Endoplasmic Reticulum DNA Strand Elongation Involved In DNA Replication Establishment Of Protein Localization Branching Involved In Mammary Gland Duct Morphogenesis DNA Strand Elongation Translational Termination Membrane Organization Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Metabolic Process MRNA Catabolic Process Transcription Factor TFIIIB Complex Assembly Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Mammary Gland Duct Morphogenesis RNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Interleukin-4 Cellular Protein Complex Disassembly Viral Life Cycle
Tagcloud ?		3a aldolase apex1 athanogene beclin1 bim bisphosphate calpain endosialin erb erythroblastic ezrin fms fructose hes1 hmgb1 hydroxysteroid metalloproteinases midkine minibrain mmps osteosarcoma polo proto recql4 shed sulfotransferase vegfa wwox
Tagcloud (Difference) ?		3a aldolase apex1 athanogene beclin1 bim bisphosphate calpain endosialin erb erythroblastic ezrin fms fructose hes1 hmgb1 hydroxysteroid metalloproteinases midkine minibrain mmps osteosarcoma polo proto recql4 shed sulfotransferase vegfa wwox
Tagcloud (Intersection) ?