RORA and LMO3

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RORA	LMO3
Gene Name		RAR-related orphan receptor A	LIM domain only 3 (rhombotin-like 2)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm
	Molecular Function	Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity	Zinc Ion Binding
	Biological Process	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Circadian Rhythm Regulation Of Smoothened Signaling Pathway Gene Expression Positive Regulation Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Hypoxia T-helper 17 Cell Differentiation Regulation Of Cholesterol Homeostasis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS		Asthma ( 20860503) Breast cancer (prognosis) ( 23319801) C-reactive protein ( 21300955) Depression (quantitative trait) ( 20800221) Gamma gluatamyl transferase levels ( 22010049) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Menarche (age at onset) ( 21102462 23599027) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume ( 21116278)
Protein-Protein Interactions		20 interactors: COPS5 EIF3I EP300 GFAP LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 ZXDC	33 interactors: AIMP2 BANP CARF CCDC33 CCDC85B CEP170P1 CEP57L1 FAM131C FBLIM1 FOS GABPB1 HNRNPC HNRNPM IKZF1 KCTD1 KXD1 LDB1 LDB2 MBIP MDFI NBPF22P NHLH2 NUTM1 PHC2 RALYL RFX6 RORA SAMD3 SP4 SPERT TAX1BP1 ZBTB43 ZBTB8A
Entrez ID		6095	55885
HPRD ID		02896	11832
Ensembl ID		ENSG00000069667	ENSG00000048540
Uniprot IDs		F1DAL0 P35398	Q8TAP4 Q9NYC6
PDB IDs		1N83 1S0X
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Cellular Metabolic Process Limbic System Development Peptidyl-lysine Modification Response To Steroid Hormone Regulation Of Cell Differentiation Histone Acetylation Positive Regulation Of Cell Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Cell Development Protein Acetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Chromatin Modification Response To Hormone Positive Regulation Of Epithelial Cell Proliferation Histone H4 Acetylation Histone Modification Regulation Of Neurogenesis	RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Purkinje Cell Layer Morphogenesis Epithelial Structure Maintenance Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Metabolic Process Chromatin Modification Cerebellar Cortex Formation Cell Differentiation In Hindbrain Cerebellar Purkinje Cell Layer Development Cellular Metabolic Process Chromatin Organization Regulation Of Myeloid Cell Differentiation Cerebellar Cortex Morphogenesis Cellular Response To Calcium Ion Histone H3 Acetylation Positive Regulation Of Neutrophil Differentiation Histone H3-K4 Acetylation Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Pancreatic Epsilon Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Calcium Ion Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Pancreatic D Cell Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation
Tagcloud ?		15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique	aggressive aggressiveness atypical benign biosignatures clinically constitute decisions demand forty fourteen histologically igf1r meningioma meningiomas metabolic mostly nmr oligonucleotide otherwise predominant proceeds profiles recur recurrence relevance subgroup subgroups turnover
Tagcloud (Difference) ?		15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique	aggressive aggressiveness atypical benign biosignatures clinically constitute decisions demand forty fourteen histologically igf1r meningioma meningiomas metabolic mostly nmr oligonucleotide otherwise predominant proceeds profiles recur recurrence relevance subgroup subgroups turnover
Tagcloud (Intersection) ?