RHEB and RABAC1

Number of citations of the paper that reports this interaction (PMID 17928295)
45

Data Source:
BioGRID (two hybrid)

		RHEB	RABAC1
Gene Name		Ras homolog enriched in brain	Rab acceptor 1 (prenylated)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome	Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Integral Component Of Membrane Cell Junction
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding Proline-rich Region Binding
	Biological Process	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of TOR Signaling
Pathways		Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling S6K1-mediated signalling IRS-related events mTOR signalling Release of eIF4E mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Release of eIF4E Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF ECSIT FKBP8 MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RPS6KB1 RPTOR TSC1 TSC2	63 interactors: ADCK3 CMTM3 CREB3 DUSP12 FAM160A2 FXR2 GDI1 HRAS HRG LNX1 MAD2L1 MCF2L MIEF2 NAT14 NDRG4 NIF3L1 NR3C2 NUDT18 PBX3 PLEKHF2 PLK1 RAB17 RAB1A RAB22A RAB33A RAB3A RAB4A RAB4B RAB5A RAB5B RAB5C RAB6A RAB7A RAP1A RASD2 REEP5 RGS2 RHEB RHOA RIC8A RIMS2 RIN3 RPS20 RRAS2 SGK1 SNCA SNX1 SNX10 SNX11 SNX15 SPG21 SYT16 TNIP1 TRIM32 TSHR TUBB2A TXN2 VAMP2 VIM VTA1 WDYHV1 WIPI2 ZFYVE21
Entrez ID		6009	10567
HPRD ID		03188	05375
Ensembl ID		ENSG00000106615	ENSG00000105404
Uniprot IDs		Q15382	Q9UI14
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Signaling Cell Communication Regulation Of Signal Transduction Response To Stress Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Response To Peptide Hormone Insulin Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Metabolic Process Response To Insulin Response To Peptide Cell Differentiation Regulation Of Protein Kinase Activity Response To External Stimulus Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Heat Cellular Response To Insulin Stimulus Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Developmental Process Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Immune System Process Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Cell Development Regulation Of Cell Size Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Response To Hypoxia Regulation Of Cellular Component Organization Regulation Of Cell Death Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Negative Regulation Of Cell Size Cellular Response To Peptide Cellular Response To Heat Cellular Response To Growth Factor Stimulus Neural Tube Development	Ras Protein Signal Transduction Rab Protein Signal Transduction Small GTPase Mediated Signal Transduction Establishment Of Protein Localization Protein Transport Protein Localization Cellular Protein Localization Cellular Localization Intracellular Protein Transport Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Endosomal Transport Regulation Of Exocytosis Transport Cellular Response To Stimulus Cell Communication Regulation Of Endocytosis Endocytosis Regulation Of Locomotion Vesicle Organization Endosome Organization Response To Stimulus Regulation Of Synaptic Vesicle Transport Regulation Of Cell Projection Organization Signaling Signal Transduction Cytoplasmic Transport Establishment Of Vesicle Localization Regulation Of Neuronal Synaptic Plasticity Vesicle Localization Regulation Of Organelle Organization Regulation Of Cell Migration Positive Regulation Of Metabolic Process Early Endosome To Late Endosome Transport Regulation Of Neurotransmitter Secretion Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cellular Localization Regulation Of Cellular Component Movement Regulation Of Cellular Process Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Transport Synaptic Vesicle Recycling Endomembrane System Organization
Tagcloud ?		abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded
Tagcloud (Difference) ?		abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded
Tagcloud (Intersection) ?