RFC3 and MESDC2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RFC3	MESDC2
Gene Name		replication factor C (activator 1) 3, 38kDa	mesoderm development candidate 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex	Cellular_component Endoplasmic Reticulum Plasma Membrane
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding ATPase Activity	Molecular_function Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Response To Organophosphorus	Protein Folding Mesoderm Development Wnt Signaling Pathway Protein Localization To Cell Surface
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: ARFGAP1 BRD4 CHTF18 CHTF8 MESDC2 PCNA RAD17 RFC1 RFC4	9 interactors: APP ATP6V1E1 BRD4 KPNB1 LRP5 PSMA5 RFC3 SNX5 SNX7
Entrez ID		5983	23184
HPRD ID		02676	12129
Ensembl ID		ENSG00000133119	ENSG00000117899
Uniprot IDs		P40938	Q14696
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Replication Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Process DNA Metabolic Process DNA Recombination Telomere Maintenance Mitotic Cell Cycle Cellular Response To Stress Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus DNA-dependent DNA Replication Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Repair Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Nuclease Activity Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Chromosome Organization Positive Regulation Of Deoxyribonuclease Activity Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Stress Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Nitrogen Compound Metabolic Process Regulation Of DNA Replication Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Homeostasis Methotrexate Transport Cellular Response To Stimulus Histone H4-K12 Acetylation Folic Acid Transport Telomere Maintenance Via Telomerase Mitotic Cell Cycle Phase Transition	Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Endocytosis Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Synaptic Growth At Neuromuscular Junction Cell-cell Signaling Involved In Mammary Gland Development Cholesterol Metabolic Process Viral Process Positive Regulation Of Canonical Wnt Signaling Pathway Sterol Metabolic Process Homeostatic Process Collateral Sprouting In Absence Of Injury Protein Transport Vesicle-mediated Transport Transition Metal Ion Homeostasis Establishment Of Protein Localization Negative Regulation Of DNA Damage Checkpoint Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Histone H3-K14 Acetylation Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Retinal Blood Vessel Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Cellular Homeostasis Extracellular Matrix-cell Signaling Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Glucose Catabolic Process Mitotic Cell Cycle Axon Choice Point Recognition Bone Marrow Development Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Vesicle Organization Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc4 rfc5
Tagcloud (Difference) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc4 rfc5
Tagcloud (Intersection) ?