SENP2 and CDCA5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SENP2	CDCA5
Gene Name		SUMO1/sentrin/SMT3 specific peptidase 2	cell division cycle associated 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Nucleoplasm PML Body Cytoplasmic Vesicle Nuclear Membrane	Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane Cohesin Complex
	Molecular Function	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding	Chromatin Binding Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Proteolysis Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Spongiotrophoblast Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Cell Division Regulation Of Cohesin Localization To Chromatin
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation Processing and activation of SUMO	Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase S Phase Mitotic Metaphase and Anaphase M Phase Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: AGTRAP APP ARL6IP1 AXIN1 CCDC155 CDCA5 CDK5RAP2 DAXX FUNDC1 IKBKG NEDD4L NUP153 PML RANGAP1 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TPD52 TRIM63	7 interactors: CDK1 IRAK3 KDM1A RPAIN SENP2 TTLL3 XRCC6
Entrez ID		59343	113130
HPRD ID		07002	13016
Ensembl ID			ENSG00000146670
Uniprot IDs		Q9HC62	Q96FF9
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cellular Localization Positive Regulation Of Protein Catabolic Process Protein Sumoylation Positive Regulation Of Cellular Protein Metabolic Process PML Body Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Mitotic Cell Cycle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process JNK Cascade Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Viral Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Stress-activated MAPK Cascade Establishment Of Organelle Localization Stress-activated Protein Kinase Signaling Cascade Nucleus Organization Cell Cycle Process Regulation Of Cellular Localization Cellular Response To Stress Mitotic Cell Cycle Process Response To Abiotic Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Organelle Localization Protein Localization To Nucleus Regulation Of Protein Localization Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Intracellular Transport Cell Surface Receptor Signaling Pathway Organelle Organization Activation Of JUN Kinase Activity Cellular Response To Stimulus Cellular Response To DNA Damage Stimulus Establishment Of Chromosome Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway	Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Binding Negative Regulation Of Intracellular Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Macrophage Tolerance Induction Regulation Of Primitive Erythrocyte Differentiation Pronuclear Fusion Negative Regulation Of Binding Toll-like Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Embryonic Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA Repair Positive Regulation Of Gene Expression Protein Polyglycylation Regulation Of DNA Replication Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Protein Modification Process Activation Of Innate Immune Response Regulation Of Protein Binding Cellular Hyperosmotic Salinity Response Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Development Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Innate Immune Response Regulation Of Cellular Protein Metabolic Process Protein Desumoylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To X-ray Positive Regulation Of Immune System Process Immune System Process Negative Regulation Of Chromatin Binding Regulation Of Schwann Cell Differentiation DNA Recombination Regulation Of Protein Metabolic Process Histone H3-K9 Demethylation Negative Regulation Of Histone H3-K4 Methylation Histone H3-K4 Demethylation Establishment Of Integrated Proviral Latency Regulation Of Innate Immune Response Regulation Of Binding Chromosome Organization
Tagcloud ?		adequate aerobic atp consistently displaying exhibit glucose glycolysis glycolytic hif1alpha knockout lactate ly294002 mcf7 mef mefs metabolism protease proteases represses rescued respiration reveals senps shifts subcellular sumo sumoylate supply
Tagcloud (Difference) ?		adequate aerobic atp consistently displaying exhibit glucose glycolysis glycolytic hif1alpha knockout lactate ly294002 mcf7 mef mefs metabolism protease proteases represses rescued respiration reveals senps shifts subcellular sumo sumoylate supply
Tagcloud (Intersection) ?