RARA and NR4A2

Number of citations of the paper that reports this interaction (PMID 7705655)
82

Data Source:
BioGRID (two hybrid, pull down)

		RARA	NR4A2
Gene Name		retinoic acid receptor, alpha	nuclear receptor subfamily 4, group A, member 2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cell Surface Actin Cytoskeleton Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Translation Repressor Activity, Nucleic Acid Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Transcription Coactivator Activity Transcription Corepressor Activity Receptor Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Phosphatidylinositol 3-kinase Regulator Activity Protein Kinase B Binding Retinoic Acid-responsive Element Binding Protein Heterodimerization Activity MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Germ Cell Development Spermatogenesis Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Intracellular Estrogen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Cytokine Multicellular Organism Growth Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Positive Regulation Of Protein Kinase B Signaling Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Sertoli Cell Fate Commitment Limb Development Face Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Estrogen Stimulus	Response To Hypoxia Neuron Migration Response To Amphetamine Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Adult Locomotory Behavior Post-embryonic Development Response To Inorganic Substance Gene Expression Death Response To Insecticide Central Nervous System Projection Neuron Axonogenesis Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Neuron Maturation Positive Regulation Of Catalytic Activity Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Transcription From RNA Polymerase II Promoter General Adaptation Syndrome Dopaminergic Neuron Differentiation
Pathways		Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		Adapalene Acitretin Alitretinoin Tazarotene Etretinate Isotretinoin Tamibarotene
Diseases
GWAS			Menarche (age at onset) ( 21102462) Response to statin therapy ( 20339536)
Protein-Protein Interactions		86 interactors: AKT1 ARID1A ARID5A ARNTL BAG1 BTG1 CCND3 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2E3 NR3C1 NR4A2 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PML PNRC2 POU2F1 PRAME PRDX6 PRKCA PSMC5 RAC3 RXRA RXRB RXRG SIRT1 SMARCD3 SMARCE1 SNW1 SP1 SPEN SRC STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIM24 TRIP4 UBE3A UBQLN1 USP7 ZBTB16	15 interactors: BAZ1B CDKN1C CDKN2D COPS5 PIAS4 PPARG RARA RARB RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 TCEAL5 VHL
Entrez ID		5914	4929
HPRD ID		06769	03493
Ensembl ID			ENSG00000153234
Uniprot IDs		A8K840 A8MUP8 B4E1J4 F1D8N9 P10276 Q6I9R7	F1D8N6 F5H4G9 P43354 Q53EL4 Q6NXU0
PDB IDs		1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM	1OVL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Multicellular Organismal Development Rhythmic Process Developmental Process Cellular Response To Hormone Stimulus System Development Cellular Response To Organic Substance Organ Development Chromatin Modification	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Retinoic Acid RNA Biosynthetic Process Heart Development Transcription From RNA Polymerase II Promoter Cardiovascular System Development Hormone-mediated Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Muscle Cell Differentiation Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Proliferation Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Heart Morphogenesis DNA-templated Transcription, Initiation RNA Metabolic Process Muscle Structure Development Aortic Smooth Muscle Cell Differentiation Nitrogen Compound Metabolic Process Gene Expression
Tagcloud ?		apl bodies compartmentalisation covalently dependant disrupted fits indirectly kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rangap1 subcellular sumo translocated ubc9	519d allograft artificial attenuate bac c19mc cxcl6 decidua evt evts extravillous feto foxl2 immunological indirectly invade microrna mirna mirnas myometrium naturally placenta placental trophoblast trophoblasts undifferentiated utr villous vts
Tagcloud (Difference) ?		apl bodies compartmentalisation covalently dependant disrupted fits kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rangap1 subcellular sumo translocated ubc9	519d allograft artificial attenuate bac c19mc cxcl6 decidua evt evts extravillous feto foxl2 immunological invade microrna mirna mirnas myometrium naturally placenta placental trophoblast trophoblasts undifferentiated utr villous vts
Tagcloud (Intersection) ?		indirectly