RANGAP1 and RANBP2

Number of citations of the paper that reports this interaction (PMID 9019411)
273

Data Source:
HPRD (in vitro, in vivo)

		RANGAP1	RANBP2
Gene Name		Ran GTPase activating protein 1	RAN binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nuclear Pore Cytoplasm Cytosol Nuclear Membrane Perinuclear Region Of Cytoplasm	Nuclear Pore Mitochondrion Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Nuclear Basket
	Molecular Function	Ran GTPase Activator Activity Protein Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Zinc Ion Binding Ran GTPase Binding Ligase Activity
	Biological Process	Mitotic Cell Cycle Signal Transduction Positive Regulation Of Ran GTPase Activity Negative Regulation Of Protein Export From Nucleus	Mitotic Cell Cycle Protein Peptidyl-prolyl Isomerization Carbohydrate Metabolic Process Protein Folding Protein Import Into Nucleus Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Glucose Transport Viral Process Protein Sumoylation Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Negative Regulation Of Glucokinase Activity Small Molecule Metabolic Process MRNA Transport Transmembrane Transport Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis
Pathways		Mitotic Prometaphase Separation of Sister Chromatids HIV Infection Host Interactions of HIV factors Rev-mediated nuclear export of HIV RNA Mitotic Anaphase Interactions of Rev with host cellular proteins M Phase Cell Cycle, Mitotic Late Phase of HIV Life Cycle HIV Life Cycle Rev-mediated nuclear export of HIV RNA Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase	Mitotic Prometaphase Separation of Sister Chromatids Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown Mitotic Anaphase SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear Pore Complex (NPC) Disassembly Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Resolution of Sister Chromatid Cohesion Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CCL5 CSNK2A1 GNAI1 GNAI3 IPO8 RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2I USPL1	34 interactors: AKAP13 ARID4B CALM1 CDCA8 CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MDM2 NUP62 NXF1 OPN1LW OPN1MW PARK2 RAN RANGAP1 SAE1 SENP1 SP100 SUMO1 TAF1 TNPO1 TOP2B TP53 UBA2 UBE2I UBTD1 XPO1 XPOT
Entrez ID		5905	5903
HPRD ID		03839	03111
Ensembl ID		ENSG00000100401	ENSG00000153201
Uniprot IDs		F8W7I9 P46060 Q9BSK3	P49792
PDB IDs		1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP	1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Protein Desumoylation Post-translational Protein Modification Peptidyl-amino Acid Modification Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Proteolysis Protein Modification By Small Protein Removal Nucleus Organization Regulation Of Cellular Protein Metabolic Process Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Division Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Signal Transduction Protein Localization To Organelle Protein Metabolic Process Signaling Cell Communication Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Binding Vesicle Fusion Protein Localization Metabolic Process Mitotic Cell Cycle Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Localization Mitotic Cell Cycle Positive Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Protein Catabolic Process	Viral Process Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Localization To Organelle Cytoplasmic Transport Peptidyl-lysine Modification Protein Import Into Nucleus Nuclear Import Cellular Localization Protein Sumoylation Protein Import NLS-bearing Protein Import Into Nucleus Positive Regulation Of Metabolic Process Cellular Protein Localization Establishment Of Localization In Cell Intracellular Transport Mitotic Cell Cycle Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Protein Localization Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization To Organelle Nuclear Export Cellular Response To Organic Substance Regulation Of Protein Localization Regulation Of Protein Catabolic Process Cell Cycle Regulation Of Intracellular Protein Transport Protein Targeting Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Establishment Of Protein Localization SMT3-dependent Protein Catabolic Process Intracellular Protein Transport Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		apl bodies compartmentalisation covalently dependant disrupted fits indirectly kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rara subcellular sumo translocated ubc9	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Difference) ?		apl bodies compartmentalisation covalently dependant disrupted fits indirectly kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rara subcellular sumo translocated ubc9	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Intersection) ?