RAB6A and BICD2

Number of citations of the paper that reports this interaction (PMID 12447383)
70

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RAB6A	BICD2
Gene Name		RAB6A, member RAS oncogene family	bicaudal D homolog 2 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cytosol Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome	Cytoplasm Golgi Apparatus Cytoskeleton Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Protein Binding Rab GTPase Binding
	Biological Process	Protein Targeting To Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Peptidyl-cysteine Methylation Antigen Processing And Presentation Rab Protein Signal Transduction Protein Localization To Golgi Apparatus Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Minus-end-directed Organelle Transport Along Microtubule	Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center
Pathways		Pre-NOTCH Processing in Golgi Signaling by NOTCH Pre-NOTCH Expression and Processing
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		20 interactors: BICD1 BICD2 CHM CHML DCTN1 ERC1 FKBP2 GDI1 GOLGA1 GOLGA2 GOLGA4 KIF20A OCRL PMM1 RAB7A RABAC1 RABGAP1 RABGGTB SYTL5 TMF1	5 interactors: DCTN1 DCTN2 GSK3B NEK9 RAB6A
Entrez ID		5870	23299
HPRD ID		01543	09826
Ensembl ID		ENSG00000175582	ENSG00000185963
Uniprot IDs		P20340 Q53ET8	Q8TD16 Q96FU2
PDB IDs		1YZQ 2GIL 3BBP 3CWZ 4DKX
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Protein Localization Establishment Of Localization In Cell Intracellular Transport Cellular Localization Protein Prenylation Protein Transport Establishment Of Protein Localization Minus-end-directed Organelle Transport Along Microtubule Cellular Protein Localization Transport Retrograde Transport, Endosome To Golgi Microtubule Anchoring At Microtubule Organizing Center Intracellular Protein Transport Vesicle-mediated Transport Microtubule-based Movement Positive Regulation Of Hydrolase Activity Microtubule-based Transport Protein Targeting To Golgi Cytoskeleton-dependent Intracellular Transport Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Protein Targeting Organelle Assembly Protein Localization To Golgi Apparatus Endosomal Transport Protein Localization To Organelle Regulation Of Proteinase Activated Receptor Activity Epidermal Growth Factor Catabolic Process Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Testosterone Secretion Positive Regulation Of Catalytic Activity Organelle Transport Along Microtubule Intra-Golgi Vesicle-mediated Transport Microtubule Anchoring Rab Protein Signal Transduction Regulation Of Catalytic Activity Luteinizing Hormone Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Androgen Secretion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Protein Localization To Organelle Microtubule-based Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Phagosome-lysosome Fusion Phagosome Acidification Negative Regulation Of Protein Targeting To Membrane	Melanosome Transport Pigment Granule Transport Antigen Processing And Presentation Cell Cycle Process Establishment Of Melanosome Localization Mitotic Nuclear Division Melanosome Localization Cell Cycle Cellular Pigmentation Retrograde Transport, Endosome To Golgi Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II ER-nucleus Signaling Pathway Mitotic Cell Cycle Process Pigmentation Establishment Of Localization In Cell G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Immune System Process Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Response To Endoplasmic Reticulum Stress Cellular Localization Minus-end-directed Organelle Transport Along Microtubule Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Peptidyl-cysteine Methylation Establishment Of Vesicle Localization Vesicle Localization Endosomal Transport Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Cellular Response To Interleukin-3 Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Protein Localization To Microtubule Microtubule-based Movement Negative Regulation Of Dendrite Morphogenesis Establishment Of Organelle Localization Negative Regulation Of NFAT Protein Import Into Nucleus ER Overload Response Early Endosome To Golgi Transport Negative Regulation Of Cardiac Muscle Hypertrophy
Tagcloud ?		autosomal axonal causal coh1 cohen constitutively disability dystrophy golgi gtpase inactive integrity intellectual interfered microcephaly neurite neuritogenesis outgrowth preferentially preparations prevents q72l recessive rnai scaffold solubilization t27n vps13b	associates bona chains cilia ciliopathies ciliopathy define dynactin dynein dynll1 dynll2 dynlrb1 dynlrb2 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Difference) ?		autosomal axonal causal coh1 cohen constitutively disability dystrophy golgi gtpase inactive integrity intellectual interfered microcephaly neurite neuritogenesis outgrowth preferentially preparations prevents q72l recessive rnai scaffold solubilization t27n vps13b	associates bona chains cilia ciliopathies ciliopathy define dynactin dynein dynll1 dynll2 dynlrb1 dynlrb2 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Intersection) ?