RAB5A and ALS2CL

Number of citations of the paper that reports this interaction (PMID 15388334)
10

Data Source:
HPRD (in vitro)

		RAB5A	ALS2CL
Gene Name		RAB5A, member RAS oncogene family	ALS2 C-terminal like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane	Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Rab GTPase Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Endosome Organization Protein Localization Positive Regulation Of Rho GTPase Activity
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL	1 interactors: RAB5A
Entrez ID		5868	259173
HPRD ID		01542	10643
Ensembl ID		ENSG00000144566	ENSG00000178038
Uniprot IDs		B4DJA5 P20339	Q60I27
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion	Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Early Endosome To Late Endosome Transport Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Exocytosis Synaptic Vesicle Recycling Regulation Of Synaptic Vesicle Transport Regulation Of Smooth Muscle Cell Migration Receptor Internalization Regulation Of Filopodium Assembly Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Rab Protein Signal Transduction Positive Regulation Of Exocytosis Regulation Of Neurotransmitter Secretion Receptor Metabolic Process Canonical Wnt Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Synaptic Vesicle Transport Regulation Of Cell Projection Assembly Regulation Of Exocytosis Regulation Of Synaptic Plasticity Regulation Of Endocytosis Establishment Of Vesicle Localization Endosomal Transport Vesicle Localization Ras Protein Signal Transduction Wnt Signaling Pathway Regulation Of Synaptic Transmission Positive Regulation Of Secretion Establishment Of Organelle Localization Regulation Of Cellular Component Size Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Receptor-mediated Endocytosis Positive Regulation Of Locomotion Regulation Of Vesicle-mediated Transport Organelle Localization Blood Coagulation Hemostasis Regulation Of Cell Projection Organization Regulation Of Body Fluid Levels Synaptic Transmission Regulation Of Cell Migration Wound Healing Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Regulation Of Secretion
Tagcloud ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Difference) ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Intersection) ?