RAB4A and DYNC1LI1

Number of citations of the paper that reports this interaction (PMID 11243854)
26

Data Source:
HPRD (two hybrid)

		RAB4A	DYNC1LI1
Gene Name		RAB4A, member RAS oncogene family	dynein, cytoplasmic 1, light intermediate chain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cytoplasm Centrosome Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity GDP Binding	Microtubule Motor Activity ATP Binding Poly(A) RNA Binding
	Biological Process	Intracellular Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Membrane Organization	Transport Microtubule-based Movement Mitotic Nuclear Division Metabolic Process Viral Process Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Aging ( 22773346)
Protein-Protein Interactions		31 interactors: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GDI2 GRIPAP1 HACE1 IDH3A KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830	4 interactors: IKBKG NUP85 RAB4A REL
Entrez ID		5867	51143
HPRD ID		01541	10917
Ensembl ID		ENSG00000168118	ENSG00000144635
Uniprot IDs		P20338	E9PHI6 Q9Y6G9
PDB IDs		1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?		Membrane Organization Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Cell Cycle Transport Regulation Of Catalytic Activity Regulation Of Cellular Localization Organelle Organization Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Protein Targeting Endocytosis Mitotic Cell Cycle Process Response To Wounding Membrane Fusion Positive Regulation Of GTPase Activity Mitotic Cell Cycle Regulation Of GTPase Activity Regulation Of Protein Localization Mitotic Nuclear Division Intracellular Transport Regulation Of Cellular Component Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Intracellular Protein Transport Organelle Fusion Regulation Of Mitotic Cell Cycle Regulation Of Establishment Of Protein Localization Blood Coagulation Cellular Protein Localization Hemostasis Regulation Of Intracellular Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Hydrolase Activity Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Membrane Docking Mitotic DNA Damage Checkpoint Positive Regulation Of Transport Regulation Of Signal Transduction Intracellular Signal Transduction Mitotic DNA Integrity Checkpoint Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Component Assembly Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Metabolic Process	NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Neuron Death Positive Regulation Of Cytokine Production Intracellular Signal Transduction Inflammatory Response Positive Regulation Of Interleukin-12 Biosynthetic Process Signal Transduction Macrophage Chemotaxis Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cytokine Production Viral Process Signaling Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway RNA Biosynthetic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Response To Cytokine Positive Regulation Of NIK/NF-kappaB Signaling B Cell Homeostasis Mitotic Nuclear Envelope Disassembly Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of NIK/NF-kappaB Signaling Innate Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Envelope Disassembly Membrane Organization Positive Regulation Of Interleukin-12 Production Lamellipodium Assembly Lamellipodium Organization RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Rab Protein Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter TRIF-dependent Toll-like Receptor Signaling Pathway Gene Expression Regulation Of Interleukin-12 Production Lymphocyte Homeostasis
Tagcloud ?		abnormally accessing anova cascades ckit decoupled dex dexamethasone ery erys erythroblast erythroblasts erythropoiesis escape expansion fdr gata1 gpr56 il3 pdgfrbeta polycythemia polycythemic pv repertoire scf tal1 tgfbeta tightly vera	a431 accumulate centrally colocalises compartment disrupts dlic dynein endosomal endosomes erc fip3 gtpase henceforth links minus onto pericentrosomal pericentrosomally periphery precedes rab11 rab11a recruits recycling sorting symbol ternary truncation
Tagcloud (Difference) ?		abnormally accessing anova cascades ckit decoupled dex dexamethasone ery erys erythroblast erythroblasts erythropoiesis escape expansion fdr gata1 gpr56 il3 pdgfrbeta polycythemia polycythemic pv repertoire scf tal1 tgfbeta tightly vera	a431 accumulate centrally colocalises compartment disrupts dlic dynein endosomal endosomes erc fip3 gtpase henceforth links minus onto pericentrosomal pericentrosomally periphery precedes rab11 rab11a recruits recycling sorting symbol ternary truncation
Tagcloud (Intersection) ?