BCAT1 and KDM1A

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		BCAT1	KDM1A
Gene Name		branched chain amino-acid transaminase 1, cytosolic	lysine (K)-specific demethylase 1A
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Branched-chain-amino-acid Transaminase Activity Identical Protein Binding L-leucine Transaminase Activity L-valine Transaminase Activity L-isoleucine Transaminase Activity	RNA Polymerase II Transcription Factor Binding P53 Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Oxidoreductase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-K9 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) MRF Binding Transcription Regulatory Region DNA Binding Flavin Adenine Dinucleotide Binding Androgen Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Cell Proliferation Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Demethylation Blood Coagulation Cell Proliferation Regulation Of Primitive Erythrocyte Differentiation Pituitary Gland Development Granulocyte Differentiation Negative Regulation Of Protein Binding Histone H3-K9 Demethylation Histone H3-K4 Demethylation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Muscle Cell Development Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Branched-chain amino acid catabolism Metabolism of amino acids and derivatives	Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HDMs demethylate histones Factors involved in megakaryocyte development and platelet production
Drugs		Pyridoxal Phosphate L-Glutamic Acid L-Leucine L-Valine L-Isoleucine N\'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
Diseases
GWAS		Response to statin therapy ( 20339536) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		3 interactors: KDM1A PRMT6 SMAD5	219 interactors: AKAP9 ANKEF1 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5J2 ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BLZF1 BMP3 BRCA1 C16orf59 C17orf82 C18orf54 C4orf17 C8orf48 C8orf74 CCDC121 CCDC14 CCDC151 CCDC155 CCDC172 CCDC37 CCDC53 CCDC74A CCDC74B CCDC90B CDC23 CDC5L CDCA4 CDCA5 CENPQ CEP162 CEP70 CRBN CRLF3 CTBP1 DBF4B DNAJA3 DNTTIP1 DYX1C1 E2F1 ECI2 ELOF1 EXOC1 EZH2 FAM9A FIGNL1 FYCO1 FYN GABPB2 GDF9 GLYR1 GOLGA2 GPATCH2L GSTCD GTPBP2 H3F3C HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HIST1H3A HIST2H3C HIST3H3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INTS2 ISL1 ITGB3BP ITSN2 KANSL1 KDM5B KIAA0408 KIFC3 KLC3 KLF3 KLHDC4 KRT17 KRT19 KRT222 KRT33B KRT38 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LOXL4 MALT1 MBD3 MBD4 MCPH1 MCRS1 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NDUFA8 NDUFS1 NECAB2 NEFL NF2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 OFCC1 OIP5 OPA3 OTUB1 PDCD5 PDE4DIP PEX7 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 RASSF1 RASSF2 RASSF8 RCOR1 RCOR3 RNF10 RPRD1A SAMD3 SEPT6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO1 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TERF1 TEX35 TEX9 TNFAIP1 TNNT2 TP53 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC33 UBA3 UCHL5 UNC119 UNKL USP28 VPS11 VPS37A WBSCR27 WDR83 YEATS4 ZBTB24 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF829
Entrez ID		586	23028
HPRD ID		00216	09800
Ensembl ID		ENSG00000060982	ENSG00000004487
Uniprot IDs		P54687	O60341
PDB IDs		2ABJ 2COG 2COI 2COJ	2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1
Enriched GO Terms of Interacting Partners?		Regulation Of Primitive Erythrocyte Differentiation Histone H3-R2 Methylation Myeloid Cell Differentiation Mullerian Duct Regression Histone Modification Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Transcription, DNA-templated RNA Biosynthetic Process Osteoblast Fate Commitment Positive Regulation Of Megakaryocyte Differentiation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H4-R3 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Chromatin Modification Anatomical Structure Regression Granulocyte Differentiation Hemopoiesis Peptidyl-arginine N-methylation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation RNA Metabolic Process Immune System Development Cellular Protein Modification Process Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Chromatin Organization Peptidyl-arginine Methylation Regulation Of Histone H3-K4 Methylation Cellular Response To BMP Stimulus Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hormone Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Histone Lysine Demethylation Regulation Of Hormone Metabolic Process Histone Demethylation Regulation Of Erythrocyte Differentiation	Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Organelle Organization Gene Expression RNA Metabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Chromosome Organization Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Cellular Component Organization Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation
Tagcloud ?		atf4 axonal believe branched cage catabolism crush ddit3 differentially dynamism eyes ganglion glaucoma highlighting ifng log2 onc optic orchestrating pathomechanisms presumably retinas revealing rgc rgcs sequenced serves silico transaminase	aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment exhibiting h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting
Tagcloud (Difference) ?		atf4 axonal believe branched cage catabolism crush ddit3 differentially dynamism eyes ganglion glaucoma highlighting ifng log2 onc optic orchestrating pathomechanisms presumably retinas revealing rgc rgcs sequenced serves silico transaminase	aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment exhibiting h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting
Tagcloud (Intersection) ?