DLGAP3 and SHANK3

Number of citations of the paper that reports this interaction (PMID 10527873)
22

Data Source:
BioGRID (two hybrid)

		DLGAP3	SHANK3
Gene Name		discs, large (Drosophila) homolog-associated protein 3	SH3 and multiple ankyrin repeat domains 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Postsynaptic Density Cell Junction Postsynaptic Membrane	Cytoplasm Plasma Membrane Cell Junction Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane Neuronal Postsynaptic Density
	Molecular Function	Beta-amyloid Binding Protein Binding	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Cell-cell Signaling	MAPK Cascade Synapse Assembly Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long Term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: DLG1 DLG3 DLG4 DLGAP1 PTK2 PTK2B SHANK2 SHANK3	15 interactors: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC SPTAN1
Entrez ID		58512	85358
HPRD ID		18935	18979
Ensembl ID		ENSG00000116544	ENSG00000251322
Uniprot IDs		O95886	D7UT47 Q9BYB0
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Receptor Clustering Synaptic Transmission Vocalization Behavior Protein Localization To Synapse Positive Regulation Of Synaptic Transmission Neuron Projection Development Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Positive Regulation Of Excitatory Postsynaptic Membrane Potential Neuron Development Regulation Of Synaptic Plasticity Positive Regulation Of Membrane Potential Social Behavior Establishment Or Maintenance Of Cell Polarity Neuron Differentiation Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Nervous System Development Neuron Projection Morphogenesis Nucleotide Phosphorylation Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Cell Morphogenesis Involved In Differentiation Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Postsynaptic Membrane Potential Regulation Of Synaptic Transmission Synapse Assembly Generation Of Neurons Signal Complex Assembly Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Protein Localization To Membrane Axon Guidance Cell Development Response To External Stimulus Dendritic Spine Morphogenesis Phosphorylation Membrane Depolarization Regulation Of Receptor Activity Regulation Of Ion Transmembrane Transport Cellular Component Assembly Cell Morphogenesis Learning Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cytoskeleton Organization Regulation Of Cytoskeleton Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Phosphorylation Cell Projection Morphogenesis Cell Part Morphogenesis Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Neuron Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Morphogenesis Neuron Differentiation Cell Projection Organization Response To External Stimulus Signaling Locomotion Cell Communication Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Actin Filament Polymerization Movement Of Cell Or Subcellular Component Cellular Response To Fibroblast Growth Factor Stimulus Response To Hormone Regulation Of Cytoskeleton Organization Response To Fibroblast Growth Factor Generation Of Neurons Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurogenesis Anatomical Structure Morphogenesis Neurotrophin Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Cell Development
Tagcloud ?			18f 5mg amygdala antidepressant aspartate baseline biomarker bipolar blind comparative completed correlates dendritic fdg hippocampus hypothesized inability ketamine limitations mri neuroimaging pathophysiology pet predicted rearrangement spine subanesthetic tesla tethering
Tagcloud (Difference) ?			18f 5mg amygdala antidepressant aspartate baseline biomarker bipolar blind comparative completed correlates dendritic fdg hippocampus hypothesized inability ketamine limitations mri neuroimaging pathophysiology pet predicted rearrangement spine subanesthetic tesla tethering
Tagcloud (Intersection) ?