RAD1 and MSH3

Number of citations of the paper that reports this interaction (PMID 20188637)
8

Data Source:
BioGRID (far western blotting)

		RAD1	MSH3
Gene Name		RAD1 checkpoint DNA exonuclease	mutS homolog 3
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle	Nuclear Chromosome Nucleus Nucleoplasm Membrane MutSbeta Complex
	Molecular Function	Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity	Y-form DNA Binding Heteroduplex DNA Loop Binding Double-strand/single-strand DNA Junction Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Centromeric DNA Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity
	Biological Process	DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis	Meiotic Mismatch Repair DNA Repair Mismatch Repair Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity
Pathways		G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: COPS5 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 PARK2 POLB RAD17 RAD9B RPA1 RPA2	12 interactors: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 XPA
Entrez ID		5810	4437
HPRD ID		04400	02931
Ensembl ID		ENSG00000113456	ENSG00000113318
Uniprot IDs		O60671	A1L480 P20585
PDB IDs		3A1J 3G65 3GGR	3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To Stress Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Recombination Cell Cycle Process Mismatch Repair DNA Replication Meiotic Mismatch Repair DNA Damage Checkpoint Cell Cycle Response To Stress Negative Regulation Of DNA Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Base-excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Telomere Maintenance Via Semi-conservative Replication Nitrogen Compound Metabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination DNA-dependent DNA Replication Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Somatic Recombination Of Immunoglobulin Gene Segments Response To UV Somatic Diversification Of Immunoglobulins Maintenance Of DNA Repeat Elements Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division Cellular Metabolic Process DNA Recombinase Assembly Cellular Response To Stimulus Mitotic Cell Cycle Immunoglobulin Production Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Somatic Hypermutation Of Immunoglobulin Genes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress DNA Recombination Cell Cycle DNA Damage Checkpoint Cell Cycle Process Cell Cycle Checkpoint DNA Replication Response To Ionizing Radiation Response To Stress Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Radiation Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Postreplication Repair Isotype Switching Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments DNA Catabolic Process DNA Catabolic Process, Exonucleolytic Double-strand Break Repair Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Nitrogen Compound Metabolic Process B Cell Activation Involved In Immune Response Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Meiotic Cell Cycle Cellular Response To Ionizing Radiation Immunoglobulin Production Protein K6-linked Ubiquitination Response To Abiotic Stimulus Cellular Response To Stimulus Intra-S DNA Damage Checkpoint Mitotic Cell Cycle Process Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Apoptotic Signaling Pathway Mitotic Cell Cycle Response To UV Cellular Metabolic Process
Tagcloud ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad9 repeats repressor rhino tethering topbp1 uv	addressed aom apc apex1 azoxymethane carcinogenesis colorectal crc dextran dss epi experimentally expressions mgmt mismatch mlh1 mlh3 mmr pilot pms1 pms2 precancerous prerequisite rectum sacrificed sequential sigmoid sulphate suppressor
Tagcloud (Difference) ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad9 repeats repressor rhino tethering topbp1 uv	addressed aom apc apex1 azoxymethane carcinogenesis colorectal crc dextran dss epi experimentally expressions mgmt mismatch mlh1 mlh3 mmr pilot pms1 pms2 precancerous prerequisite rectum sacrificed sequential sigmoid sulphate suppressor
Tagcloud (Intersection) ?