BAX and SLC25A4

Number of citations of the paper that reports this interaction (PMID 9748162)
154

Data Source:
HPRD (two hybrid, in vivo)

		BAX	SLC25A4
Gene Name		BCL2-associated X protein	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Pore Complex Extracellular Vesicular Exosome Bcl-2 Family Protein Complex BAX Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Lipid Binding Channel Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Protein Binding Adenine Transmembrane Transporter Activity
	Biological Process	Ovarian Follicle Development Neuron Migration T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Germ Cell Development Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Apoptotic Mitochondrial Changes Fertilization Response To Toxic Substance Response To Salt Stress Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Viral Process Hypothalamus Development Cerebral Cortex Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Oligomerization Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Within A Tissue Protein Oligomerization Protein Homooligomerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Mitochondrion Morphogenesis Cellular Response To Organic Substance Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Retinal Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitochondrial Genome Maintenance Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Transport Apoptotic Mitochondrial Changes Adenine Transport Viral Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Negative Regulation Of Necroptotic Process
Pathways		Activation, translocation and oligomerization of BAX Programmed Cell Death Intrinsic Pathway for Apoptosis	Integration of energy metabolism Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization HIV Infection Regulation of insulin secretion Host Interactions of HIV factors Mitochondrial protein import Interactions of Vpr with host cellular proteins
Drugs			Adenosine triphosphate Clodronate [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium Carboxyatractyloside Cardiolipin Di-Stearoyl-3-Sn-Phosphatidylcholine
Diseases
GWAS
Protein-Protein Interactions		25 interactors: BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID BNIPL ERN1 KCNA3 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 SNCA UHRF2 VDAC1 YWHAB YWHAQ ZBTB24	7 interactors: AR BAX NFKBIA NR3C1 PPID PPIF PRKCE
Entrez ID		581	291
HPRD ID		02498	00058
Ensembl ID		ENSG00000087088	ENSG00000151729
Uniprot IDs		Q07812	P12235
PDB IDs		1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Release Of Cytochrome C From Mitochondria Mitochondrion Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Mitochondrial Membrane Permeability Regulation Of Signaling Positive Regulation Of Intracellular Transport Regulation Of Membrane Permeability Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Endopeptidase Activity Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Regulation Of Peptidase Activity Regulation Of Mitochondrial Membrane Potential Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cellular Response To Lipid Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Transport Regulation Of Signaling Regulation Of Protein Localization Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Organic Cyclic Compound Negative Regulation Of Transporter Activity Negative Regulation Of Apoptotic Process Programmed Necrotic Cell Death Negative Regulation Of Programmed Cell Death Necrotic Cell Death Negative Regulation Of Cell Death Negative Regulation Of Transmembrane Transport Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cellular Response To UV Cellular Response To Stimulus Mitochondrial Membrane Organization Response To Abiotic Stimulus Negative Regulation Of Transport Intracellular Steroid Hormone Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Organelle Organization Apoptotic Mitochondrial Changes Positive Regulation Of Neuron Death
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Tagcloud (Difference) ?		androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl	aberrantly af anr atrial autonomic bioinformatics canine copyright dysregulated fgf19 fgf3 fgf4 fibrillation filtering inducibility lentiviruses lncrnas nearby neurogenesis orchestrators pads pipelines prolong reserved rights shorten tcons transcriptomes twofold
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