PTPRZ1 and ARHGAP35

Number of citations of the paper that reports this interaction (PMID 16513268)
18

Data Source:
HPRD (in vitro)

		PTPRZ1	ARHGAP35
Gene Name		protein tyrosine phosphatase, receptor-type, Z polypeptide 1	Rho GTPase activating protein 35
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Integral Component Of Plasma Membrane Perineuronal Net	Nucleus Cytosol Actin Cytoskeleton
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Transcription Corepressor Activity Rho GTPase Activator Activity GTP Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Axonogenesis Central Nervous System Development Learning Or Memory Peptidyl-tyrosine Dephosphorylation Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Transcription, DNA-templated Small GTPase Mediated Signal Transduction Axon Guidance Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Forebrain Development Positive Regulation Of Rho GTPase Activity Negative Regulation Of Rho Protein Signal Transduction Camera-type Eye Development Negative Regulation Of Vascular Permeability Negative Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Axon guidance Semaphorin interactions Signaling by Rho GTPases Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 MDK PTN TNR	5 interactors: HDAC1 KRT31 PTPRZ1 RHOA SRC
Entrez ID		5803	2909
HPRD ID		01481	05592
Ensembl ID		ENSG00000106278	ENSG00000160007
Uniprot IDs		B4DFE7 C9JFM0 P23471	Q9NRY4
PDB IDs		3JXF 3S97	2K85 3C5H 3FK2
Enriched GO Terms of Interacting Partners?		Nervous System Development System Development Neuron Differentiation Multicellular Organismal Development Locomotion Anatomical Structure Development Movement Of Cell Or Subcellular Component Forebrain Development Developmental Process Generation Of Neurons Neuron Development Neurogenesis Cell Development Chemotaxis Learning Or Memory Cognition Cell Morphogenesis Involved In Differentiation Cell Differentiation Brain Development Head Development Neuron Projection Development Cell Migration Axon Guidance Cell Motility Learning Central Nervous System Development Single-organism Behavior Regulation Of Cell Morphogenesis Response To External Stimulus Cell Morphogenesis Regulation Of DNA-templated Transcription, Initiation Organ Development Regulation Of Cellular Component Organization Axonogenesis Cell Projection Organization Axon Development Negative Regulation Of Neuron Death Cell Morphogenesis Involved In Neuron Differentiation Behavior Neuron Projection Morphogenesis Regulation Of Neurogenesis Regulation Of Cell Division Regulation Of Apoptotic Process Regulation Of Neuron Death Telencephalon Development Regulation Of Cell Death Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Epithelium Development Blood Coagulation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Hemostasis Regulation Of Cell Proliferation Axonogenesis Viral Process Axon Development Tissue Development Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Response To Growth Factor Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Cell Morphogenesis Involved In Differentiation Neuron Projection Development Anatomical Structure Development Cellular Response To Progesterone Stimulus Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cell Cycle Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal Muscle Satellite Cell Migration Neuron Development Platelet Activation Central Nervous System Development Developmental Process Cell-cell Junction Organization Cell Morphogenesis Ras Protein Signal Transduction Bone Development Positive Regulation Of Integrin Activation Positive Regulation Of Podosome Assembly Negative Regulation Of Mitochondrial Depolarization Neuron Differentiation Cell Projection Organization Organ Development
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?