MARK4 and RPTOR

Number of citations of the paper that reports this interaction (PMID 23184942)
2

Data Source:
BioGRID (enzymatic study)

		MARK4	RPTOR
Gene Name		MAP/microtubule affinity-regulating kinase 4	regulatory associated protein of MTOR, complex 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Neuron Projection	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Dendrite TORC1 Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Gamma-tubulin Binding Ubiquitin Binding Tau-protein Kinase Activity	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Binding Protein Kinase Binding Protein Complex Binding 14-3-3 Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Organelle Organization Nervous System Development Positive Regulation Of Programmed Cell Death	Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Insulin Receptor Signaling Pathway Regulation Of Cell Size Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase III Promoter Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane	IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R HSF1-dependent transactivation Release of eIF4E Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Release of eIF4E Cellular response to heat stress S6K1-mediated signalling mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Obesity ( 23563607)
Protein-Protein Interactions		28 interactors: CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MTUS2 NEDD4 NOTCH2NL ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP RPTOR STK11 TUBA4A TUBB TUBG1 UBC YWHAB YWHAH YWHAZ	20 interactors: AKT1S1 EIF4EBP1 ICK IRS1 IRS2 MAPK1 MAPK3 MARK4 MLST8 MTOR PLD2 PRKAA1 PRKAA2 PRR5L RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB
Entrez ID		57787	57521
HPRD ID		09402	06184
Ensembl ID		ENSG00000007047	ENSG00000141564
Uniprot IDs		Q96L34	F5H7J5 Q6DKI0 Q8N122
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Localization G2/M Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Establishment Of Localization In Cell Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Golgi Localization Regulation Of Cell Projection Organization Positive Regulation Of Transport Cell Cycle Cell Cycle Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neuron Development Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Microtubule Cytoskeleton Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Cell Morphogenesis Response To Stimulus Microtubule-based Process Regulation Of Apoptotic Process Cellular Response To Organic Substance Cellular Component Assembly Establishment Of Golgi Localization Neuron Differentiation Cytoskeleton Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Axonogenesis Regulation Of Cellular Component Organization Neuron Projection Development Negative Regulation Of ERBB Signaling Pathway Regulation Of Cell Death Generation Of Neurons Membrane Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Glucocorticoid Receptor Signaling Pathway Neurogenesis	Cellular Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Peptide Hormone Enzyme Linked Receptor Protein Signaling Pathway Regulation Of TOR Signaling Response To Peptide Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cell Communication Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Response To Heat Response To Hormone Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Heat Fc-epsilon Receptor Signaling Pathway Response To Stimulus TOR Signaling Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Cellular Response To Heat Positive Regulation Of TOR Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?		acetate activator antimetastatic ap atra benzamido benzoic bis consequently cytotoxicity derivative includes interfering inverted l5 metalloproteinase mmp noncytotoxic partly plasminogen proteolytic question tac tetradecanoylphorbol tpa trimethylsilyl urokinase zymographic	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Difference) ?		acetate activator antimetastatic ap atra benzamido benzoic bis consequently cytotoxicity derivative includes interfering inverted l5 metalloproteinase mmp noncytotoxic partly plasminogen proteolytic question tac tetradecanoylphorbol tpa trimethylsilyl urokinase zymographic	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Intersection) ?