PTH2R and PTH

Number of citations of the paper that reports this interaction (PMID 9482662)
0

Data Source:
HPRD (in vivo)

		PTH2R	PTH
Gene Name		parathyroid hormone 2 receptor	parathyroid hormone
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Parathyroid Hormone Receptor Activity	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Hormone Activity Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Bone Mineralization Positive Regulation Of CAMP Biosynthetic Process Response To Vitamin D Cellular Macromolecule Biosynthetic Process Response To Drug Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Response To Parathyroid Hormone Response To Fibroblast Growth Factor
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Bone mineral density ( 19874204)
Protein-Protein Interactions		5 interactors: CALM1 GRHPR HMG20A PTH PTH2	5 interactors: BAG6 FEZ1 MEP1A PTH1R PTH2R
Entrez ID		5746	5741
HPRD ID		03276	01345
Ensembl ID		ENSG00000144407	ENSG00000152266
Uniprot IDs		P49190	P01270
PDB IDs			1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Fibroblast Growth Factor Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Anoikis Regulation Of High Voltage-gated Calcium Channel Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Glyoxylate Metabolic Process Negative Regulation Of Gene Expression Response To Metal Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Glycogen Biosynthetic Process Response To Parathyroid Hormone Negative Regulation Of Anoikis Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Inorganic Substance Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Anoikis Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Response To Vitamin D
Tagcloud ?		alters articular cdk2 cdks cfk2 cfk2r chondrocyte chondrocytes chondrocytic clones generating hypertrophic lesser localizing master metalloproteinase newborn parathyroid plate prehypertrophic presently resting restricting skeleton sox9 substantiating tip39 tuberoinfundibular	accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 parathyroid pg porcine proximity scintillation simply spa spiked throughput
Tagcloud (Difference) ?		alters articular cdk2 cdks cfk2 cfk2r chondrocyte chondrocytes chondrocytic clones generating hypertrophic lesser localizing master metalloproteinase newborn plate prehypertrophic presently resting restricting skeleton sox9 substantiating tip39 tuberoinfundibular	accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 pg porcine proximity scintillation simply spa spiked throughput
Tagcloud (Intersection) ?		parathyroid