BIRC6 and DIABLO

Number of citations of the paper that reports this interaction (PMID 15200957)
38

Data Source:
HPRD (in vivo, in vitro)

		BIRC6	DIABLO
Gene Name		baculoviral IAP repeat containing 6	diablo, IAP-binding mitochondrial protein
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Endosome Trans-Golgi Network Microtubule Organizing Center Membrane Midbody	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Ligase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Spongiotrophoblast Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways			Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response SMAC binds to IAPs Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: BIRC5 CASP3 CASP7 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 HTRA2 MAP2K1 PLK1 RAB8A RNF41 UBC UBE2D1 USP8 VAV2	20 interactors: AREL1 ARL6IP1 ARNT BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 EEF1A1 HTRA2 LTBR MAML2 NGFRAP1 NR4A1 SLC25A47 UBE2K UFM1 XIAP ZNF746
Entrez ID		57448	56616
HPRD ID		05731	05560
Ensembl ID		ENSG00000115760	ENSG00000184047
Uniprot IDs		Q9NR09	K7X1S0 Q502X2 Q9NR28
PDB IDs		3CEG	1FEW 1G3F 1G73 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cell Death Apoptotic Signaling Pathway Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Mitotic Cell Cycle Process Positive Regulation Of Peptidase Activity Negative Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Mitotic Cell Cycle Proteolysis Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Cellular Macromolecule Catabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Protein Catabolic Process Zymogen Activation Neurotrophin TRK Receptor Signaling Pathway	Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Protein Ubiquitination Negative Regulation Of Protein Processing Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Necroptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Signaling Intracellular Signal Transduction Protein Metabolic Process Regulation Of Neuron Death
Tagcloud ?		alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft	angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
Tagcloud (Difference) ?		alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft	angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
Tagcloud (Intersection) ?