PTBP1 and PCBP2

Number of citations of the paper that reports this interaction (PMID 10772858)
48

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		PTBP1	PCBP2
Gene Name		polypyrimidine tract binding protein 1	poly(rC) binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly-pyrimidine Tract Binding Pre-mRNA Binding Poly(A) RNA Binding	DNA Binding RNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Muscle Cell Differentiation	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression MRNA Metabolic Process Negative Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Negative regulators of RIG-I/MDA5 signaling mRNA Splicing - Major Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APBB1 APP CALCOCO2 CASP3 ELAVL1 FUS HIST3H3 HMGA1 HMGA2 HNRNPAB HNRNPK HNRNPL IL7R NONO PCBP1 PCBP2 PCBP3 PRKACA QKI RAVER1 RAVER2 RBFOX2 RBM10 SFPQ SNRPA SRPK2 ZMYM2	25 interactors: BARD1 CASK CNBP FLNA HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL NKAP PABPC1 PAXIP1 PCBP1 PRPF40A PTBP1 QKI SF3B2 SLU7 SNRPA SRSF3 SRSF7 WDR77 WDR83 YBX1 YBX3
Entrez ID		5725	5094
HPRD ID		02823	03129
Ensembl ID		ENSG00000011304	ENSG00000197111
Uniprot IDs		P26599	B4DXP5 F8VZX2 G3V0E8 Q15366
PDB IDs		1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 3ZZY 3ZZZ	2AXY 2JZX 2P2R 2PQU 2PY9
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Oncogene-induced Cell Senescence Positive Regulation Of Gene Expression Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Cellular Metabolic Process Positive Regulation Of Cell Aging Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Heterochromatin Assembly Cell Morphogenesis DNA Metabolic Process Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Heterochromatin Organization DNA Catabolic Process, Endonucleolytic Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Stress Regulation Of Cellular Senescence Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway DNA Repair Chromatin Modification Cell Development Regulation Of Stem Cell Maintenance Response To Light Stimulus Positive Regulation Of Cell Death DNA Catabolic Process Cellular Senescence Chromosome Organization Extracellular Matrix Organization	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Oncogene-induced Cell Senescence Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of MRNA Processing MRNA Stabilization Regulation Of Nitrogen Compound Metabolic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Gene Expression Positive Regulation Of Cellular Senescence Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Aging Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translation Heterochromatin Assembly Biosynthetic Process MRNA 3'-end Processing Heterochromatin Organization Positive Regulation Of Cellular Metabolic Process Regulation Of MRNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Translation
Tagcloud ?		aminobutyric ampa amphibians calmodulin camkiialpha clathrin demonstrations elongated exclude fiber gaba immunoblot intriguingly isoxazolepropionic lens lenses morphogenetic neurogenesis nonsense parallels polypyrimidine protrusions psd ptbp2 scaffold spacing spine splicing	9b aip4 atg5 clue coronaviruses cov depended dynamin etiologic evade evades fission havoc hect illustrates localizes manipulates mavs mitochondria orf outbreak proteasomal sars signalosome traf traf3 triggering uncovered usurping
Tagcloud (Difference) ?		aminobutyric ampa amphibians calmodulin camkiialpha clathrin demonstrations elongated exclude fiber gaba immunoblot intriguingly isoxazolepropionic lens lenses morphogenetic neurogenesis nonsense parallels polypyrimidine protrusions psd ptbp2 scaffold spacing spine splicing	9b aip4 atg5 clue coronaviruses cov depended dynamin etiologic evade evades fission havoc hect illustrates localizes manipulates mavs mitochondria orf outbreak proteasomal sars signalosome traf traf3 triggering uncovered usurping
Tagcloud (Intersection) ?