JPH2 and CAV3

Number of citations of the paper that reports this interaction (PMID 15541368)
27

Data Source:
HPRD (in vivo)

		JPH2	CAV3
Gene Name		junctophilin 2	caveolin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Z Disc Junctional Membrane Complex	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Z Disc T-tubule Neuromuscular Junction Vesicle Sarcolemma Membrane Raft
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-5-phosphate Binding Calcium-release Channel Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Calcium Channel Regulator Activity Protein Binding Protein C-terminus Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Protein Complex Binding Protein Complex Scaffold Alpha-tubulin Binding Ion Channel Binding Nitric-oxide Synthase Binding Connexin Binding
	Biological Process	Regulation Of Cardiac Muscle Tissue Development Calcium Ion Homeostasis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport	Plasma Membrane Repair Regulation Of Heart Rate Negative Regulation Of Protein Kinase Activity Triglyceride Metabolic Process Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Protein Localization Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Cell Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Muscle Cell Cellular Homeostasis Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Nerve Growth Factor Receptor Activity Nucleus Localization Regulation Of Protein Kinase B Signaling Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Establishment Of Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: CAV3	15 interactors: DAG1 DYSF EGFR GNAS INSR JPH2 NOS1 PCBP1 PDGFRA PDGFRB PFKM PTGES3 SENP1 SLC22A11 SLC8A1
Entrez ID		57158	859
HPRD ID		12006	03154
Ensembl ID		ENSG00000149596	ENSG00000182533
Uniprot IDs		Q86VZ3 Q9BR39	P56539
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development T-tubule Organization Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Membrane Depolarization During Action Potential Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Cell Differentiation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Caveolin-mediated Endocytosis Caveola Assembly Negative Regulation Of Protein Localization To Cell Surface Regulation Of Skeletal Muscle Contraction Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Plasma Membrane Repair Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Membrane Raft Assembly Negative Regulation Of Monooxygenase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of P38MAPK Cascade Negative Regulation Of Cell Size Heart Trabecula Formation Regulation Of Sarcomere Organization Regulation Of Protein Localization To Cell Surface Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Striated Muscle Cell Differentiation Membrane Raft Organization Myoblast Fusion Negative Regulation Of Cardiac Muscle Tissue Development Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport Membrane Assembly Regulation Of Calcium Ion Import Negative Regulation Of Oxidoreductase Activity Membrane Biogenesis Muscle Cell Cellular Homeostasis Heart Trabecula Morphogenesis Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Microtubule Polymerization Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Hypertrophy	Homeostatic Process Chemical Homeostasis Wound Healing Organ Morphogenesis Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process Positive Regulation Of The Force Of Heart Contraction Response To Wounding Positive Regulation Of Transport Exocrine System Development Regulation Of Calcium Ion Transport Positive Regulation Of Phospholipase C Activity Response To Organonitrogen Compound Glomerular Capillary Formation Cellular Response To Organonitrogen Compound Protein Autophosphorylation Cardiac Muscle Cell Development Positive Regulation Of DNA Replication Striated Muscle Cell Differentiation Metanephric Glomerulus Vasculature Development Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Metanephric Glomerulus Development Glomerulus Morphogenesis Regulation Of MAPK Cascade Regulation Of Cell Motility Interaction With Host Anatomical Structure Morphogenesis Tissue Development Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Cellular Component Movement Response To Organic Substance Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion
Tagcloud ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable
Tagcloud (Difference) ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable
Tagcloud (Intersection) ?