DPYSL5 and DARS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DPYSL5	DARS2
Gene Name		dihydropyrimidinase-like 5	aspartyl-tRNA synthetase 2, mitochondrial
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Gene Ontology Annotations	Cellular Component	Cytosol Dendrite Neuronal Cell Body	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance	TRNA Aminoacylation For Protein Translation Gene Expression TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling	tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: APPL1 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5	4 interactors: AIMP2 DPYSL5 EPHA8 KARS
Entrez ID		56896	55157
HPRD ID		10522	07677
Ensembl ID		ENSG00000157851	ENSG00000117593
Uniprot IDs		Q9BPU6	Q6PI48 Q9H9J7
PDB IDs		4B90 4B91 4B92	4AH6
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Folding In Endoplasmic Reticulum Nervous System Development Small Molecule Metabolic Process Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Neuron Differentiation Cerebellum Structural Organization Uracil Catabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Beta-alanine Metabolic Process Uracil Metabolic Process Thymine Metabolic Process Thymine Catabolic Process Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Neurogenesis Positive Regulation Of Glutamate Secretion TRNA Aminoacylation For Mitochondrial Protein Translation Cell Development Regulation Of Cell Development Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Asparaginyl-tRNA Aminoacylation Protein Homooligomerization ER Overload Response	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Lysyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process TRNA Metabolic Process Type II Pneumocyte Differentiation Pyrimidine Nucleobase Catabolic Process Neuron Remodeling Axon Guidance Lung Secretory Cell Differentiation Cellular Amino Acid Metabolic Process NcRNA Metabolic Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Small Molecule Metabolic Process Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Translation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Maturation Cell Morphogenesis Involved In Differentiation Substrate-dependent Cell Migration Pyrimidine Nucleobase Metabolic Process Regulation Of Cell Adhesion Mediated By Integrin Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Development Lung Epithelial Cell Differentiation Regulation Of Lipid Kinase Activity Carboxylic Acid Metabolic Process Lung Cell Differentiation Cell Differentiation Cell Morphogenesis Lung Epithelium Development Neuron Differentiation Organic Acid Metabolic Process Cell Projection Organization Locomotion Ephrin Receptor Signaling Pathway
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