PRNP and RPL41

Number of citations of the paper that reports this interaction (PMID 18482256)
4

Data Source:
BioGRID (pull down)

		PRNP	RPL41
Gene Name		prion protein	ribosomal protein L41
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Cytosol Cytosolic Large Ribosomal Subunit
	Molecular Function	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding	RNA Binding Structural Constituent Of Ribosome
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs		Tetracycline
Diseases
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)	Systemic sclerosis ( 21779181)
Protein-Protein Interactions		76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740	7 interactors: APP CSNK2B IKBKG MAPK14 NUPR1 PRNP SRPK2
Entrez ID		5621	6171
HPRD ID		01453	17999
Ensembl ID		ENSG00000171867	ENSG00000229117
Uniprot IDs		B2NI04 F7VJQ1 P04156 Q53YK7	P62945
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I	3J3B
Enriched GO Terms of Interacting Partners?		Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Defense Response Cellular Copper Ion Homeostasis Chemotaxis Copper Ion Homeostasis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Response To External Stimulus Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Cellular Component Assembly Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway Cell Death Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cell Morphogenesis Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Axon Guidance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway System Development MyD88-dependent Toll-like Receptor Signaling Pathway Anatomical Structure Morphogenesis Toll-like Receptor 4 Signaling Pathway Locomotion Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Growth Protein Phosphorylation
Tagcloud ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	11th anxa2 balb blastn differentially enriched euthanized infected inoculated inoculation messenger myeloma nktr parasite perform putative ranged rbbp4 sequenced sizes sp2 spiralis ssh subcutaneously subtractive trichinella twenty utilized weights
Tagcloud (Difference) ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	11th anxa2 balb blastn differentially enriched euthanized infected inoculated inoculation messenger myeloma nktr parasite perform putative ranged rbbp4 sequenced sizes sp2 spiralis ssh subcutaneously subtractive trichinella twenty utilized weights
Tagcloud (Intersection) ?