MAPK13 and MAPKAPK3

Number of citations of the paper that reports this interaction (PMID 9207191)
60

Data Source:
HPRD (in vitro)

		MAPK13	MAPKAPK3
Gene Name		mitogen-activated protein kinase 13	mitogen-activated protein kinase-activated protein kinase 3
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Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Stress Response To Osmotic Stress Cell Cycle Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Macropinocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways		Signalling to ERKs Signalling by NGF DSCAM interactions Signaling by VEGF Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Innate Immune System	Signalling to ERKs Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade p38MAPK events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by VEGF Oxidative Stress Induced Senescence Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4	16 interactors: APP COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK11 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A SMS SUMO3 TCF3
Entrez ID		5603	7867
HPRD ID		09113	03678
Ensembl ID		ENSG00000156711	ENSG00000114738
Uniprot IDs		O15264	Q16644
PDB IDs		3COI 4EXU 4EYJ 4EYM	3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Adult Locomotory Behavior Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Activation Of MAPK Activity Regulation Of Protein Phosphorylation Adult Behavior Toll-like Receptor 5 Signaling Pathway Developmental Process Toll-like Receptor 10 Signaling Pathway Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Response To Stress Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAP Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta2 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Modification Process Locomotory Behavior MyD88-dependent Toll-like Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Toll-like Receptor Signaling Pathway Response To Organic Substance Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cell Communication Regulation Of Kinase Activity	Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Muscle Cell Differentiation Posttranscriptional Regulation Of Gene Expression Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Gene Expression Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Peptidyl-amino Acid Modification Negative Regulation Of Sodium Ion Transport Positive Regulation Of Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Organic Substance Response To Stress Regulation Of Kinase Activity Regulation Of Phosphorylation Skeletal Muscle Tissue Regeneration Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Immune System Process Platelet Activation Regulation Of Potassium Ion Transmembrane Transport Regulation Of Gene Expression Protein Monoubiquitination Regulation Of Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade
Tagcloud ?		alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1	ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus
Tagcloud (Difference) ?		alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1	ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus
Tagcloud (Intersection) ?